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43 Antiviral drugs > Drugs for HIV 1 (NRTIs + NNRTIs) > Flashcards

Drugs for HIV 1 (NRTIs + NNRTIs) Flashcards

1
Q

Drugs for HIV (4 groups)

A

Reverse transcriptase inhibitors
Protease inhibitors (PIs)
Fusion and entry inhibitors
Integrase strand transfer inhibitor

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2
Q

Reverse transcriptase inhibitors (2 groups)

A

Nucleoside reverse transcriptase inhibitors (NRTIs)

Nonnucleoside reverse transcriptase inhibitors (NNRTIs)

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3
Q

NRTIs (7 drugs)

A 
Didanosine 
Lamivudine
Stavudine
Emtricitabine
Zidovudine (ZDV)
Abacivir (ABC)
Tenofovir
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4
Q

How does tenofovir differ from the other NRTIs?

A

It’s a nulcleotide (not nucleoside) reverse transcriptase inhibitor.

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5
Q

NRTIs - MOA

A

Triphosphate metabolites of the drugs compete with nucleoside triphosphates for incorporation into viral DNA. Cause DNA chain termination.
Inhibit host cell DNA polymerase somewhat.

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6
Q

NRTIs - adverse effects

A

Lactic acidosis
Hepatic steatosis
Lipodystrophy

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7
Q

NRTIs - indications

A

HIV

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8
Q

Which NRTI can also be used for hepatitis B?

A

Lamivudine

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9
Q

First line and alternative to first line drugs for HIV (2 drugs)

A

Didanosine (1st line)

Stavudine (alternative)

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10
Q

Which NRTIs have antagonistic activity?

A

Stavudine and Zidovudine (should not be used together)

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11
Q

NRTI with high incidence of adverse effects

A

Stavudine

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12
Q

NRTIs that may cause pancreatitis (2 drugs)

A

Stavudine and Didanosine

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13
Q

Zidovudine - adverse effects

A

Bone marrow suppression

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14
Q

NNRTIs (3 drugs)

A

Efavirenz
Nevirapine
Delavirdine

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15
Q

Contraindications for NNRTIs

A

Hepatic impairment

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16
Q

Adverse effects of NNRTIs

A

Steven-Johnson syndrome
Hepatotoxicity
Drug interactions

17
Q

NNRTIs which interacts with many drugs

A

Nevirapine

18
Q

Most potent NNRTI

A

Efavirenz

19
Q

Efavirenz - contraindications

A

Pregnancy

Hepatic impairment

20
Q

Which NNRTI may cause neuropsychiatric reactions?

A

Efavirenz

43 Antiviral drugs (5 decks)

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