Drugs for Psychosis from Dr. Smith

Question 1

Schizophrenia and psychosis is linked to excess _______ in the brain

Therefore ________ antagonism is the main MOA of all antipsychotic meds

Answer 1

dopamine

Question 2

What is our high-potency, typical, anti-psychotic?

Answer 2

Haloperidol

Question 3

muscle spasms of various muscle groups and prolonged muscular contractions, usually of the head and neck

Answer 3

Acute dystoniaas

Question 4

How do we treat acute dystonia?

Answer 4

IM anticholinergic agents

Question 5

Late-onset EPS. Characterized by choreoathetosis and other involuntary sucking and smacking of lips and mouth

Answer 5

Tardive dyskinesia

Question 6

Hyperpyrexia, extrapyramidal rigidity, severe ANS dysfunction, myoglobinuria, lead-pipe rigidity, and sometimes death

Answer 6

Neuroleptic Malignant Syndrome

Question 7

Low potency typicals often have a high rate of _____ side effects but a low rate of ______. Conversely, high-potency typicals often have a low rate of _______ side effects but a high rate of _______.

Answer 7

Ach, EPS

Ach, EPS

Question 8

Side effects of 2nd generation anti-psychotics – the “pine” drugs specifically

Answer 8

Metabolic stuff

Obesity, hyperglycemia, and hyperlipidemia

Question 9

Major side effect from Olanazpine [Zyprexa]?

Answer 9

Weight gain

Question 10

“__________ is the most effective anti-psychotic drug, but it should be reserved for refractory disease because of its potential for serious hematologic toxicity and strict monitoring requirements.”

Answer 10

Clozapine

Question 11

The “-done” drugs cause what type of side effects?

Answer 11

Neurological