Drugs in Pregnancy Labor and Lactation Flashcards Preview

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Flashcards in Drugs in Pregnancy Labor and Lactation Deck (28)
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1

Factors that influence drugs’ passage across placenta

2

How drugs affect fetus

3

How drugs affect the fetus depends on

4

Stages at which fetus is affected

5

Effect of drugs administered during implantation stage

May lead to failure of pregnancy

eg. Methotrexate (anticancer drug)

       Alcohol

6

Effect of drugs adminstered during organogenesis 

7

Teratogenicity of thalidomide

8

Teratogenicity of Retinoids

Skeletal deformities (strong)

9

Teratogenicity of methotrexate 

Cleft palate/hydrocephalus 

10

Teratogenicity of Phenytoin 

11

Teratogenicity of Valproate

12

Teratogenicity of Warfarin

Nasal hypoplasia 

13

Teratogenicity of diethylstilbestrol

Adenocarsinoma of vagina in teenage years of the daughter

14

Teratogenecity during the G and D stage

15

Drugs given at end of pregnancy ie before or during labor

16

Effect of Asprin

17

Effects of Sulfonamides

18

Effect of BZDs and Opiates

19

More teratogenic drugs

20

FDA RISK CATEGORIES 

21

Effect of Pregnancy on Distribution 

22

Effect of drug on elimination

23

Common chronic conditions in pregnancy 

24

Concerns with antiepileptic drugs

25

Factors controlling transfer of drug to breast milk

  • Lipid solu
  • MW
  • Ionization
  • Blood flow

Note: most enter blood but at small amounts

26

Drugs safe during breast feeding

27

Drugs avoided during breast feeding

28

Minimizing effects during breast feeding

  • Avoid if possible
  • Safest effective medicine
  • LOWEST possible dose
  • Take immediately after breast feeding
  • Lactation risk guidelines