Drugs - mechanisms of action

Question 1

Mirtazapine

Answer 1

NaSSA
5HT2 antagonist
5HT3 antagonist
H1 antagonist
A1 antagonist
A2 antagonist
Muscarinic antagonist

Question 2

Venlafaxine

Answer 2

SNRI

Question 3

Duloxetine

Answer 3

SNRI

Question 4

Reboxetine

Answer 4

NaRI

Question 5

St John’s Wort

Answer 5

Weak MAOi
Weak SNRI
Weak SSRI

Question 6

Trazodone

Answer 6

SARI
5HT1A - antagonist, blocks SERT (antidepressant effect)
5HT2A - antagonist, blocks SERT
5HT2C - antagonist, blocks SERT

Question 7

Moclobemide

Answer 7

Reversible MAOi

Question 8

Agomelatine

Answer 8

MT1 agonist
MT2 agonist
5HT2C antagonist

Question 9

Bupropion

Answer 9

NDRI

Nicotinic Ach antagonist

Question 10

Donepezil

Answer 10

Reversible AChEi

Question 11

Rivastigmine

Answer 11

Reversible AChEi

Butyrylcholinesterase inhibitor

Question 12

Galantamine

Answer 12

Reversible AChEi

Binds allosterically to the nicotinic acetylcholine receptor

Question 13

Memantine

Answer 13

Non-competitive NMDA antagonist

Question 14

Valproate

Answer 14

GABA agonist

NMDA antagonist

Question 15

Gabapentin

Answer 15

Binds to voltage-activated calcium channels

Question 16

Topiramate

Answer 16

GABA agonist
NMDA antagonist
Na+ channel stabiliser

Question 17

Carbamazepine

Answer 17

Na+ channel stabiliser

Question 18

Phenytoin

Answer 18

Na+ channel stabiliser

Question 19

Lamotrigine

Answer 19

NMDA antagonist

Na+ channel stabiliser

Question 20

Pregabalin

Answer 20

Potent ligand for the alpha-2-delta subunit of voltage-gated calcium channels in the CNS

Question 21

Benzodiazepines

Answer 21

GABA-A agonist

Question 22

Z-drugs

Answer 22

GABA-A agonist

Question 23

Buspirone

Answer 23

5HT1A partial agonist

Question 24

Flumazenil

Answer 24

GABA-A antagonist

Question 25

Amisulpride

Answer 25

D2 antagonist | D3 antagonist

Question 26

Olanzapine

Answer 26

Dopamine antagonist | 5HT2 antagonist

Question 27

Aripiprazole

Answer 27

Partial agonist D2 Partial agonist 5HT1A 5HT2A antagonist

Question 28

Clozapine

Answer 28

Dopamine antagonist (esp D4) 5HT1A partial agonist 5HT2 antagonist

Question 29

Lurasidone

Answer 29

``` D2 antagonist 5HT2A antagonist 5HT7 antagonist Alpha blocker Partial agonist 5HT1a ```

Question 30

Ketamine

Answer 30

NMDA antagonist

Question 31

Clonidine

Answer 31

A2 agonist

Question 32

Buprenorphine

Answer 32

Partial mu-opioid agonist

Question 33

Naloxone

Answer 33

Pure opioid antagonist

Question 34

Atomoxetine

Answer 34

NaRI

Question 35

Varenicicline

Answer 35

Nicotinic receptor partial agonist

Question 36

Disulfiram

Answer 36

Irreversible binding to acetaldehyde dehydrogenase/

Question 37

Acamprosate

Answer 37

Glutamate receptor antagonist | GABA-A agonist

Question 38

Selegiline

Answer 38

Irreversible MAOi

Question 39

Sildenafil

Answer 39

Inhibits cGMP-specific PDE5