Drugs modifying cardiac rate and force Flashcards Preview

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Flashcards in Drugs modifying cardiac rate and force Deck (19):
1

Blocker of HCN channels?

Ivabradine

2

Vagal tone on the heart

Vagal tone slows the intrinsic heart rate from ~100bpm to ~70bpm

3

Nerve supply to the SA and AV node

vagus nerve

4

Nerve supply to SA node, AV node and myocardium

Sympathetic

5

Lead I

RA to LA

6

Lead 2

RA - LL

7

Lead 3

LA - LL

8

P

Atrial depolarisation

9

QRS

Ventricular depolarisation

10

T

Ventricular repolarisation

11

PR interval

AV node delay

12

ST segment

Ventricular systole

13

TP interval

diastole

14

Dobutamine, selective?

Yes, beta 1 adrenoceptors

15

Metoprolol
Atenolol
Propanolol
Which are selective?

Metoprolol + atenolol are beta-1 antagonists

Propanolol is non selective

16

Adverse effects of beta blockers?

Bronchospasm
Aggravation of cardiac failure
Bradycardia
Hypoglycemia
Fatigue
Cold extremities

17

Clinical uses of atropine (increases heart rate)

To reverse bradycardia following myocardial infarction (in which vagal tone is elevated)
As an adjunct to anaesthesia
In anticholinesterase poisoning (to reduce excessive parasympathetic activity)

18

Which transporter does digoxin block?

Blocks the NA+/K+ATPase

19

Binds to troponin C in cardiac muscle sensitising it to the action of Ca2+

Levosimendan (calcium sensitiser)