Flashcards in Lipid metabolism Deck (23):
Contain apoA1 and apoA2
formed in intestinal cells and transport dietary triglycerides – the exogenous pathway
particles are formed in liver cells and transport triglycerides synthesised in that organ – the endogenous pathway
Drug treatment for high LDL
Statin and ezetimibe
Drug treatment for raised LDL and VLDL
Fibrates, statin, nicotinic acid
Drug treatment for high VLDL
Drug treatment for raised chlyomicrons and VLDL
Fibrates, niacin, fish oil and statin combination
HMG-CoA reductase inhibitors
Decrease in hepatocyte cholesterol synthesis causes a compensatory increase in LDL receptor expression and enhanced clearance of LDL
Name a condition where statins would be useless
Familial hypercholesterolaemia where HDL receptors are lacking
Other beneficial effects of statins
Reversal of endothelial dysfunction
Stabilization of atherosclerotic plaques
Adverse effects of statins?
(incidence increased if statin combined with fibrate!!)
Who shouldn't you give fibrates to?
Adverse effects of fibrates?
First line treatment for high TG
Colestyramine, colestipol, colsevelam
Bile acid binding resins
Adverse effects of bile acid binding resins
GI tract irritation
Exetimibe, what is it?
Inhibits Niemann-Pick C1 like- 1
-inhibits cholesterol absorption
When is ezetimibe contraindicated?
In breast feeding females