Lipid metabolism Flashcards Preview

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Flashcards in Lipid metabolism Deck (23):
1

Contain apoA1 and apoA2

HDL

2

Contain apoB-100

LDL

3

Contain apoB-100

VLDL

4

Contain apoB-48

Chylomicrons

5

formed in intestinal cells and transport dietary triglycerides – the exogenous pathway

Chylomicrons

6

particles are formed in liver cells and transport triglycerides synthesised in that organ – the endogenous pathway

VLDL

7

Drug treatment for high LDL

Statin and ezetimibe

8

Drug treatment for raised LDL and VLDL

Fibrates, statin, nicotinic acid

9

Drug treatment for high VLDL

Fibrates

10

Drug treatment for raised chlyomicrons and VLDL

Fibrates, niacin, fish oil and statin combination

11

HMG-CoA reductase inhibitors

Statins

12

Decrease in hepatocyte cholesterol synthesis causes a compensatory increase in LDL receptor expression and enhanced clearance of LDL

Statins

13

Name a condition where statins would be useless

Familial hypercholesterolaemia where HDL receptors are lacking

14

Other beneficial effects of statins

Decreased inflammation
Reversal of endothelial dysfunction
Decreased thrombosis
Stabilization of atherosclerotic plaques

15

Adverse effects of statins?

Myositis
Rhabdomyolosis
(incidence increased if statin combined with fibrate!!)

16

Who shouldn't you give fibrates to?

Alcoholics

17

Adverse effects of fibrates?

Myositis
Rhabdomyolosis
GI symptoms
Pruritis
Rash

18

First line treatment for high TG

Fibrates

19

Colestyramine, colestipol, colsevelam

Bile acid binding resins

20

Adverse effects of bile acid binding resins

GI tract irritation

21

Exetimibe, what is it?

Inhibits Niemann-Pick C1 like- 1
-inhibits cholesterol absorption

22

When is ezetimibe contraindicated?

In breast feeding females

23

Adverse effects of ezetimibe?

Diarrhoea, abdominal pain and headache