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Flashcards in drugs of abuse Deck (45):
1

molec target of PCP, ketamine

NMDAR

2

ectasy long term use effects:

cognitive impairment

3

effect opoids

euphoria

4

long term effects LSD

flashbacks of altered perception yrs after consumption

5

withdrawal symp: n/v, m aches, lacrimation, rhinorrhea, mydriasis, piloerection, sweating, drh, yawning, fever

opioid withdrawal

6

efects: euphoria, relaxation, feelings of well-being, grandiosity, altered perception of passage of time, withdrawn, bloodshot eyes

cannabinoids

7

MOA amphetamines

-reversing action fo biogenic amine transporers at PM --> increased DA, SE, NE in synapse

8

effects: eupohria, enhanced sensory perceptions, feelings of social closeness, amnesia before sedation/coma

GHB

9

withdrawal: dysphoria, drowsiness (insomnia), irritability, depression

amphetamines

10

THC analogs used medically

dronabinol, nabilone

11

drugs to end addiction to nicotine

nicotine (gum, losenge, inhalers, transdermal applications), bupropion, varenicline

12

use of dronabinol

anorexia and wt loss in AIDS and chemo induced n/v

13

MOA GHB

-activities GABAb --> hyperpolarizes DA neurons and prevents DA release
-recreational doses: inhibit GABAb

14

MOA methadone, buprenophrine

long-acting opioids used for substiturino therapy

15

cociane binds to.. and MOA

DAT,=> increases DA conc in nuc accumbens
NET => blocks = activates sympathetics => HBP, tachy, ventricualr arrythmias, pupil dilation
SERT

16

what are the nonaddictive drugs of abuse?

LSD
mescaline
psilocybin
PCP
ketamine

17

common opoids used

morphine, heroin, coedine, oxycodone, meperidine

18

effects: loss appetite, hyperactivity, lack sleep, incrased risk intracranial hem, ischemic stroke, MI, seizures

cociane

19

Drugs that activate Gio-coupled receptors

opoids, cannabinoids, GHB

20

tx opoid withdrawal

naloxone, methadone, buprenophrine

21

effect of opoids, cannabinoids, GHB on DA neurons

disinhibition

22

ectasy binds to..

SERT > DAT, NET

23

withdrawal symp: mood offset: long depression and agression

ectasy

24

long term effects PCP

schizophrenia-like psychosis

25

withdrawal: restlessness, irritabilty, mild agiatation, insomnia, n, cramping

cannabinoids

26

overdose management inhalants

supportive care

27

drugs that mediate theri effects via ionotropic receptors

nicotine, benzodiazepines/barbituates, alch, inhalants

28

effect inhalants

eupohria

29

drugs that bind to transporters of biogenic amines

cocaine, amphetamines, ectasy

30

MOA varenicline

-partial nAchR agonist
-->prevents nicotine stimulation of mesolimbic DA system assoc w nicotine addiction

31

MOA ectasy

-reversing action fo biogenic amine transporers at PM --> increased DA, SE, NE in synapse

32

MOA opoids

inhibs GABA -->disinhib DA

33

MOA naloxone

opoid antagonist

34

use of nabilone

refractory n/v assoc w CA chemo and adjunct to chronic pain managment

35

why we use bupropion

-antidepressant
-end nicotine addiciton

36

effect of LSD, mescaline, psilocybin, PCP, ketamine on DA?

none bc nonaddictive

37

SEs: psychedelic, HBP, impaired mem, disorientatino, nystagmus, visual alterations

PCP
ketamine

38

molec target LSD, mescaline, psilocybin

Gq

39

withdrawal: mild: irritabilty, sleeplessness

nicotine withdrawal

40

amphetamnes binds to..

DAT, SERT, NET, VMAT

41

cannabinoids MOA

-bind to presynap CB1 receptors and inhib release glutamate/GABA
-disinhibit DA

42

tx for cocaine overdose

supportive: control HR/R (propranolol), seizures (diazepam)

43

overdose: hyperthermia, coma, death

cociane

44

nicotine MOA

agonist nAchR --> DA release!

45

effects: hyperthermia, dehydration, serotonin synd (mental status change, autonomic hyperactivity, neuromusc abns), seizures

ectasy