drugs of abuse

Question 1

molec target of PCP, ketamine

Answer 1

NMDAR

Question 2

ectasy long term use effects:

Answer 2

cognitive impairment

Question 3

effect opoids

Answer 3

euphoria

Question 4

long term effects LSD

Answer 4

flashbacks of altered perception yrs after consumption

Question 5

withdrawal symp: n/v, m aches, lacrimation, rhinorrhea, mydriasis, piloerection, sweating, drh, yawning, fever

Answer 5

opioid withdrawal

Question 6

efects: euphoria, relaxation, feelings of well-being, grandiosity, altered perception of passage of time, withdrawn, bloodshot eyes

Answer 6

cannabinoids

Question 7

MOA amphetamines

Answer 7

-reversing action fo biogenic amine transporers at PM –> increased DA, SE, NE in synapse

Question 8

effects: eupohria, enhanced sensory perceptions, feelings of social closeness, amnesia before sedation/coma

Answer 8

GHB

Question 9

withdrawal: dysphoria, drowsiness (insomnia), irritability, depression

Answer 9

amphetamines

Question 10

THC analogs used medically

Answer 10

dronabinol, nabilone

Question 11

drugs to end addiction to nicotine

Answer 11

nicotine (gum, losenge, inhalers, transdermal applications), bupropion, varenicline

Question 12

use of dronabinol

Answer 12

anorexia and wt loss in AIDS and chemo induced n/v

Question 13

MOA GHB

Answer 13

• activities GABAb –> hyperpolarizes DA neurons and prevents DA release
• recreational doses: inhibit GABAb

Question 14

MOA methadone, buprenophrine

Answer 14

long-acting opioids used for substiturino therapy

Question 15

cociane binds to.. and MOA

Answer 15

DAT,=> increases DA conc in nuc accumbens
NET => blocks = activates sympathetics => HBP, tachy, ventricualr arrythmias, pupil dilation
SERT

Question 16

what are the nonaddictive drugs of abuse?

Answer 16

LSD
mescaline
psilocybin
PCP
ketamine

Question 17

common opoids used

Answer 17

morphine, heroin, coedine, oxycodone, meperidine

Question 18

effects: loss appetite, hyperactivity, lack sleep, incrased risk intracranial hem, ischemic stroke, MI, seizures

Answer 18

cociane

Question 19

Drugs that activate Gio-coupled receptors

Answer 19

opoids, cannabinoids, GHB

Question 20

tx opoid withdrawal

Answer 20

naloxone, methadone, buprenophrine

Question 21

effect of opoids, cannabinoids, GHB on DA neurons

Answer 21

disinhibition

Question 22

ectasy binds to..

Answer 22

SERT > DAT, NET

Question 23

withdrawal symp: mood offset: long depression and agression

Answer 23

ectasy

Question 24

long term effects PCP

Answer 24

schizophrenia-like psychosis

Question 25

withdrawal: restlessness, irritabilty, mild agiatation, insomnia, n, cramping

Answer 25

cannabinoids

Question 26

overdose management inhalants

Answer 26

supportive care

Question 27

drugs that mediate theri effects via ionotropic receptors

Answer 27

nicotine, benzodiazepines/barbituates, alch, inhalants

Question 28

effect inhalants

Answer 28

eupohria

Question 29

drugs that bind to transporters of biogenic amines

Answer 29

cocaine, amphetamines, ectasy

Question 30

MOA varenicline

Answer 30

- partial nAchR agonist | - ->prevents nicotine stimulation of mesolimbic DA system assoc w nicotine addiction

Question 31

MOA ectasy

Answer 31

-reversing action fo biogenic amine transporers at PM --> increased DA, SE, NE in synapse

Question 32

MOA opoids

Answer 32

inhibs GABA -->disinhib DA

Question 33

MOA naloxone

Answer 33

opoid antagonist

Question 34

use of nabilone

Answer 34

refractory n/v assoc w CA chemo and adjunct to chronic pain managment

Question 35

why we use bupropion

Answer 35

- antidepressant | - end nicotine addiciton

Question 36

effect of LSD, mescaline, psilocybin, PCP, ketamine on DA?

Answer 36

none bc nonaddictive

Question 37

SEs: psychedelic, HBP, impaired mem, disorientatino, nystagmus, visual alterations

Answer 37

PCP | ketamine

Question 38

molec target LSD, mescaline, psilocybin

Answer 38

Gq

Question 39

withdrawal: mild: irritabilty, sleeplessness

Answer 39

nicotine withdrawal

Question 40

amphetamnes binds to..

Answer 40

DAT, SERT, NET, VMAT

Question 41

cannabinoids MOA

Answer 41

- bind to presynap CB1 receptors and inhib release glutamate/GABA - disinhibit DA

Question 42

tx for cocaine overdose

Answer 42

supportive: control HR/R (propranolol), seizures (diazepam)

Question 43

overdose: hyperthermia, coma, death

Answer 43

cociane

Question 44

nicotine MOA

Answer 44

agonist nAchR --> DA release!

Question 45

effects: hyperthermia, dehydration, serotonin synd (mental status change, autonomic hyperactivity, neuromusc abns), seizures

Answer 45

ectasy