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Flashcards in sedative hyp drugs Deck (22):
1

drugs indicated for m relaxation

diazepam and meptobamate
*NOT the new drugs

2

benzo favored as a hypnotic rather thena sedative and why

triazolam bc short elim half life (2-3 hrs)

3

which drug increases total sleep time

eszopiclone

4

SEs: dizziness, somnolence, fatigue, endo changes (decrease T and increases prolactin

ramelton

5

drugs used for better sleep onset

zalepon, zolpidem, ramelton

6

drugs ehh for sleep probs and yay for sleep probs:

ehh:
-secobarbital, pentobarbital, chloral hydrate
-benzos bc cause daytime dedation

yay:
-zaleplon and zolpidem if trouble going to sleep
-eszopiclone if wake early and not back

7

best and worst benzos for hepatic dis

best: lorazepam and oxazepam (<20h 1/2 life)
worst: diazepam and chlordiazepoxide (>100h 1/2 life)

8

good drugs for anesthesia and why

thiopental and methohexital bc are very lipid soluable and penetrate brain rapidly after IV admin

9

which drug causes daytime anxiety when it is used to tx sleep disorders?

triazolam bc short 1/2 life of 4 hours

10

short term relief of anxiety: promotes sleep in anxious ans tense pt

meprobamate

11

ramelteon MOA

agonist M1 and M2 on suprachiasmic nuclei

12

drugs indicated for seizure management

clonazapam, nitrazepam, lorazepam, diazepam; phenobarbital
*NOT the new drugs

13

which drugs induce CYP450?

phenobarbital and meptobamate

14

for generalized anxiety disorder

buspirone

15

which benzos if hepatic insufficiency and why

oxazepam and lorazepam bc less cumulative toxcity bc less hepatic biotransformation compared to diazepam

16

benzos used for IV anesthesia in combo w other drugs

diazepan, lorazepam, midazolam

17

whick drugs tx withdrawl from physiologic dependence of alch or other sedative-hypnotocs

chlordiazepoxide and diazepam

18

which drugs ahve less withdrawl symp?

zolpidem, zaleplon, eszopiclone (less so than benzos at least)

19

which drug class for acute anxiety attacks?

benzos

20

use w caution in hepatic impairment

ramelton, buspirone,

21

SE's: tachy, palpitations, nervousness, GI issues, paresthesias, dose-dependent papillaty constriction

buspirone

22

which drugs induce hepatic CYPs

phenobarbital and meprobamate