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Pharmacology by THer > Drugs of Abuse > Flashcards

Drugs of Abuse Flashcards

1
Q

Define: Compulsive Drug-using behavior

A

Addiction

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2
Q

Define: Decreased response to a drug

A

Tolerance

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3
Q

Identify Etiology of tolerance:

increased disposition of the drug

A

Metabolic Tolerance

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4
Q

Identify Etiology of tolerance:

ability to compensate for the effects of a drug

A

Behavioral Tolerance

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5
Q

Identify Etiology of tolerance:

Changes in receptor or effector systems involved in drug actions

A

Functional Tolerance

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6
Q

Abstinence syndrome is also known as

A

Withdrawal syndrome

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7
Q

Dopamine in the __________ of the brain appears to play a role in reward.

A

Mesolimbic System

Excess dopamine stimulation may lead to pathologic reinforcement

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8
Q

Enumerate: Amphetamines

A

Detroamphetamine

Metamphetamine

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9
Q

Identify Drug:
Feeling of euphoria and self-confidence
In chronic high dose, can lead to psychotic state, necrotizing arteritis (leading to cerebral hemorrhage and renal failure)

A

Amphetamines

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10
Q

Pathophysiology of Amphetamine Overdose

A

Increased release of catecholamines

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11
Q

Tx for Amphetamine overdose

A

No antidote
Control body temp
Protect against cardiac arrhythmia and seizures

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12
Q

Pathophysiology of Amphetamine Withdrawal

A

It’s like from overdrive to crashing

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13
Q

Tx for Amphetamine withdrawal

A

Antidepressants (amineptin, mirtazapine) are of limited benefit
Acidify urine to increase elimination

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14
Q

Similar drugs to Amphetamines

Congeners

A

DOM
MDA
MDMA (Ecstasy)

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15
Q

Effects of Similar drugs to Amphetamines (Congeners)

A

more selective action on serotonin transporters
facilitate interpersonal communication
acts as sexual enhancers
depletion of neurons in serotonergic tracts

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16
Q

Sx of MDMA Overdose

A 
Profound hyponatremia
Serotonin Syndrome
Heart
Kidney
CNS
17
Q

Tx for MDMA Overdose

A 
Supportive care (control seizures, hyperthermia, and serotonin syndrome)
Fluid resuscitation with HYPERTONIC SALINE for hyponatremia
18
Q

Cocaine has similar effects to this drug

A

Amphetamine

19
Q

Effects of Cocaine

A

Short-lasting euphoria, self confidence and mental alertness

20
Q

Sx of Cocaine Overdose

A 
Mydriasis (Nakakita ka ng Coke, nanlaki mata mo)
Crack Lung (Hemorrhagic Alveolitis)
21
Q

Tx for Cocaine Overdose

A

No specific antidote

Supportive care

22
Q

When used in pregnancy, this drug is associated with increased fetal morbidity and mortality

A

Cocaine

23
Q

Sx of Cocaine withdrawal: Stimulating/Depressive?

A

Depressive

24
Q

Tx for Cocaine Withdrawal

A

Antidepressant drugs may be incidated

25
Q

Infants born to mothers who abused this drug can have Cystic Cortical Lesions

A

Cocaine

26
Q

Enumerate Phencyclidine Agents

A

Phencyclidine

Ketamine

27
Q

Effects of Phencyclidine

A

Antagonists of Glutamate NMDA

No actions on Dopa neurons in the CNS

28
Q

Most dangerous hallucinogenic agent

A

PCP

Psychomimetic

29
Q

Sx of Phencyclidine Overdose

A

Horizontal and Vertical Nystagmus

Fatal Seizures

30
Q

Tx for Phencyclidine Overdose

A

Parenteral benzodiazepines (Diazepam, Lorazepam) to curb excitation and protect against seizures

31
Q

Enumerate Miscellaneous HALLUCINOGENIC Agents

A

LSD
Mescaline
Psilocybin

32
Q

Effects of Hallucinogenic Agents

A

Psychedelic and mind ravelling effects
Marked somatic effects
Panic reactions

33
Q

Active ingredient in Marijuana

A

Tetrahydrocannabinol (THC)

34
Q

More potent and partially purified Marijuana is called

A

Hashish

35
Q

Effects of Marijuana are potentiated by concomitant use of _____________ like ethanol

Class?

A

Sedative - Hypnotics

36
Q

Effects of marijuana

A 
Dream like state
Vasodilation
Tachycardia
Reddened conjunctiva (Bloody Mari(juana) = Red)
Dry mouth
(ANTICHOLINERGIC! Like atropine)

Pharmacology by THer (31 decks)

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