Adrenoreceptor Blockers

Question 1

Irreversible Alpha nonselective blocker (forms covalent bond with alpha receptors) (A1>A2)
Drug for pheochromocytoma
SE: orthostatic hypotension, reflex tachycardia

Answer 1

Phenoxybenzamine

Question 2

Reversible alpha nonselective blocker (A1>A2)
Drug for rebound hypertension in Clonidine, pre surgical Pheochromocytoma, antidote for alpha1 agonist overdose
SE: Orthostatic hypotension, reflex tachycardia

Answer 2

Phentolamine

Question 3

Alpha1 selective blocker
Drug for BPH
SE: first dose orthostatic hypotension, less chance for refelx tachycardia

Answer 3

Prazosin
(Doxazosin, Terazosin, Tamsulosin, Silodusin)
Tamsulosin is most selective for prostatic smooth muscle
Take at night to avoid orthostatic hypotension

Question 4

Advantage of alpha1 selectivity

Answer 4

Reflex tachycardia is less common and less severe

Question 5

Drug Class of Isoproterenol

Answer 5

Non Selective Beta AGONIST

I SOrry, kala ko Beta Blocker ka

Question 6

Non selective beta blocker
Drug for HPN, Hyperthyroidism, angina prophylaxis
SE: Bronchospasm, erectile dysfunction
Masks initial symptoms of hypoglycemia (tachycardia, tremor, anxiety) in diabetics

Answer 6

Propranolol

Pindolol, Timolol, Labetalol, Carvedilol, Nadolol

Question 7

Drugs with combined alpha and beta blockade

May be used for hypertension in Pheochromocytoma

Answer 7

Carvedilol

Labetalol

Question 8

Side Effect of Beta blockers on DIabetics

Answer 8

Can mask premonitory symptoms of hypoglycemia (i.e. Tachycardia, tremor, anxiety)
Impaired hepatic mobilization of glucose

Question 9

Beta agonists that are less likely to cause bronchospasm
(with intrinsic sympathomimetic activity)
Advantage in pxs with asthma

Answer 9

Pindolol
Acebutolol

ISA PA!

Question 10

Side effects of beta blockers when used topically in the eye

Answer 10

Decreases protective reflexes

Increases risk for corneal ulceration

Question 11

Beta Blockers with Absent Local Anesthetic activity

Answer 11

Timolol
Betaxolol

Treat Bulag

Question 12

Beta blocker with longest half life

Answer 12

Nadolol

NAsa DOLO

Question 13

Beta1 selective blocker
Drugs for HPN, Heart failure, SVT
SE: less likely to cause bronchospasm, erectile dysfunction
Masks initial symptoms of hypoglycemia (tachycardia, tremor, anxiety) in diabetics

Answer 13

Atenolol

Betaxolol, Esmolol (SVT), Acebutolol, Metoprolol

Question 14

Beta blocker with the shortest half-life

Answer 14

Esmolol

ESMOL = small = shortest half life

Question 15

Nonselective alpha blockers

Answer 15

Phenoxybenzamine

Phentolamine