Drugs Of Abuse Part 2 Flashcards Preview

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Flashcards in Drugs Of Abuse Part 2 Deck (22):
1

Name 3 CNS Depressants

Alcohol (Ethanol)
Barbiturates
Benzodiazepines

2

By what mechanism does Ethanol have its effects.

Potentiates GABA-A mediated inhibition.
Inhibits presynaptic calcium channels.
Inhibition of NMDA receptor function.

3

What are the Effects of Ethanol?

Motor incoordination.
Slurred speech.
Increased self confidence.
Euphoria
Melancholy.
Agression.
Submission.
Inhibition of ADH.
Inhibition of Respiration.

4

What are the peripheral effects of Ethanol?

Vasodilation.
Increase in salivary and gastric secretion.

5

describe dependence level, withdrawal and subsequent treatment for Ethanol.

Dependence level High.
Withdrawal - Headache
Nausea
Tremor
Convulsions.
Treatment - Disulfiram
Diazepam
Chlordiazepoxide
Clonidine.

6

Name the mechanism and effects of Barbiturates.

Mechanism - Enhancement of GABA-A mediated inhibition.
Effects - Anxiolytic
Sedation
Unconsciousness
Coma
Death
Respiratory Depression.

7

Describe the dependence and withdrawal symptoms of Barbiturates.

Dependence - Very High
Withdrawal - Insomnia
Convulsion
Anxiety.

8

Name the mechanism and effects of Benzodiazepines.

Mechanism - Enhancement of GABA- A mediated inhibition.
Effects - Anxiolytic
Sedative
Muscle Relaxant
Anticonvulsant.

9

Describe dependence, withdrawal symptoms and treatment for Benzodiazepines.

Dependence level - Moderate.
Withdrawal - Insomnia
Anxiety
Convulsions.
Treatment - Flumazenil.

10

Name 3 Opioids.

Morphine
Diacetylmorphine - (Heroin)
Pethidine

11

By what mechanism do Opioids have their effect?

Stimulation of Mu, Delta and Kappa receptors.
Inhibition of cAMP
Inhibition of presynaptic calcium channels.
Facilitate opening of K+ channels.

12

What are the effects of Opioids?

Analgesia
Sedation
Euphoria
Nausea and Vomiting
Respiratory depression.
Miosis.

13

What are the peripheral effects for opioids?

Constipation.
Histamine Release

14

Describe dependence, withdrawal and treatment for Opioids.

Dependence - Very high.
Withdrawal - Severe opioid craving.
Dysphoria.
Insomnia.
Piloerection.
Nausea and vomiting.
Cold clammy skin.
Treatment - Methadone
Naloxone.
Natrexone
Clonidine.

15

Name 3 Hallucinogens.

LSD
Cannabis (Delta-9-Tetrahydrocannabinol).
MDMA.

16

By what mechanism does LSD have its effects.

Agonist and 5-HT-1 Receptors.
ntagonist and 5-HT-2 Receptors.
Supression of firing at Raphe Nuclei correllating with psychotominetic activity.

17

What are the effects of LSD?

Hallucinations
Synesthesia
Confusion of senses
Paranoid delusions
Time distortion
"Bad Trips"

18

What's the dependence level of LSD?

Low.

19

Describe the mechanism and effects of MDMA.

Increase of 5-HT (Serotonin) and Dopamine Release.
Euphoria.
Mildly Hallucinogenic.
Increased energy.
Empathy.
Sever Hyperthermia.

20

Dependence level of ecstasy (MDMA)

Low.

21

Describe the mechanism and effects of Cannabis (Delta - 9 - Tetrahydrocannabinol)

Stimulates Cannabinoid receptors (CB1)
Mild Hallucinogen
Anxiolytic
Euphoria
Paranoia
Relaxation.
Increased appetite.

22

What's the dependence level of Cannabis (Delta-9-Tetrahydrocannabinol.)

Dependence Low.