Drugs Week 1 Flashcards Preview

Neuro Mike Rose > Drugs Week 1 > Flashcards

Flashcards in Drugs Week 1 Deck (13):
1

Methotrexate

MOA: Inhibit DHFR and thus decreasing nucleotide synthesis and DNA replication.

CCS: S phase

Side effects: Bone marrow suppression, nausea, vomitting

2

5 Fluorouracil

Inhibit Pyrimidine synthesis of Thiamine blocking DNA synthesis.

CCS: S phase

Side effects: Bone marrow suppression, nausea, vomitting

3

ARA - C

Inhibit pyrimidine synthesizing enzymes.

CCS: S phase

4

Fludarabine

Inhibits purine synthesizing enzymes

CCS: S phase

5

Busulfan

DNA alkylating agent. Damages DNA.

CCNS

6

Cyclophosphamide

DNA alkylating agent. Damages DNA

CCNS

7

Temozolamide (TMZ)

DNA alkylating agent. Damages DNA.

Crosses BBB well. Small, Lipophilic, not effluxed.

Prodrug--> given orally.

First line for Glioblastoma, but extremely expensive with limited gains.

CCNS

8

Carmustine (BCNU)

DNA alkylating agent. Damages DNA.

Some BBB crossing. Large, somewhat lipophilic, and efflux pumps somewhat effected

Can be implanted as a wafer into brain.

CCNS

9

Doxorubicin

DNA intercalting agent. Damages DNA

CCNS

10

Etoposide

Causes strand breaks during replication. Damages DNA

CCS: S phase

11

Paclitaxel

Overstabilizes spindle formation. Interupts mitosis.

CCS: M phase

12

Vincristine

Blocks spindle formation. Interupts mitosis.

Doesn't cross BBB well. Large, lipophilic, and effluxed.

CCS: M phase.

13

Amphotericin B

Systemic antifungal that binds erg11 and creates holes in membrane.

Must be given IV. Used for systemic fungal infections especially in the immunocompromised. Broad fungal spectrum.

Can cross BBB: Large, Lipophilic, and effluxed.
Side effects: severe nephrotoxicity