drying

Question 1

what are the two types of manufacturing?

Answer 1

primary and secondary

Question 2

what is primary manufacturing used for?

Answer 2

synthesis of actives

Question 3

what is secondary manufacturing used for?

Answer 3

production of dosage forms

Question 4

what is primary manufacturing?

Answer 4

water can degrade many types of drugs
hydrolytic degradation is highly discouraged
dry product is generally free flowing

Question 5

what happens in secondary manufacturing

Answer 5

wet granulation is used to make formulation prior to tablet compaction
stability, compaction and flow properties are influenced by residual water content.

Question 6

what is total moisture content?

Answer 6

total water content in wet solid
not all of this water content is easily removed but the one that is easily removed is known as unbound water or free moisture content.

Question 7

what is equilibrium moisture content?

Answer 7

all solids equilibrate with the moisture in air
this water is called equilibrium moisture content

Question 8

what are the three methods of determining moisture content

Answer 8

dynamic sorption
karl fischer titration
thermogravimetric analysis

Question 9

what is dynamic vapour sorption

Answer 9

weight change as function of temperature and humidity

Question 10

what is thermogravimetric analysis?

Answer 10

weight change as function of temperature