DSA Fundamentals of Biochemical Reactions Flashcards Preview

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Flashcards in DSA Fundamentals of Biochemical Reactions Deck (11)
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1
Q

What is Le Chateliers principle (Mass action)

A

States that Keq can be manipulated by altering the concentrations of products and reactants. +Change(G) reactions can be driven to the right by increasing reactants and decreasing products

2
Q

Input of energy (Coupled reactions)

A

Allows endergonic reaction to be coupled to an exergonic reaction in order for the former to occur
-They must share a common intermediate

3
Q

How do kidneys regulate blood pH

A

By removing H+ and reabsorption of HCO3-

In high pH, less H+ is secreted (as NH4+) and less bicarbonate is reabsorbed

4
Q

Breathing responses to metabolic acidosis and alkalosis

A

Acidosis- Hyperventilation

Alkalosis- Hypoventilation

5
Q

Metabolic acidosis and alkalosis are caused by what, respectively

A

Acidosis- diarrhea

Alkalosis- vomiting (loss of acid)

6
Q

Coenzymes vs cofactors

A

Cofactors are typically metal ions

Coenzymes are usually vitamin derived

7
Q

What is the importance of each of these coenzymes- copper, iron, zinc

A

Cu- Energy production
Iron- Heme/oxygen delivery
Zinc- Metabolic enzyme function

8
Q

Explain hypochlorhydria

A

Can be caused by using proton pump inhibitors. Decreased HCl in stomach can decrease nutrient absorption and increase sensitivity to food poisoning

9
Q

Uncompetitive vs noncompetitive inhibitors

A

Non-competitive bind to ES or E complexes - decreased Vmax

Uncompetitive only bind ES complex- Decreased Vmax and Km

10
Q

How do chelating factors work in general, how does lead act as one, and how can lead poisoning be treated

A

Bind metal ions and inhibit them from performing their function as cofactors
Lead inhibits Ferrocheletase, administration of Ca-EDTA will help because Pb has higher affinity for EDTA than Calcium

11
Q

Troponin/CK-MB in myocardial infarction

A

They will both be elevated and are test markers for MI

Troponin is a key molecule for muscle contractions