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Therapeutics 2 - Exam 5 > Dyslipidemia lab > Flashcards

Dyslipidemia lab Flashcards

(48 cards)

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1
Q

Atorvastatin brand

A

Lipitor

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2
Q

rosuvastatin brand

A

crestor

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3
Q

simvastatin brand

A

zocor

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4
Q

pravastatin brand

A

pravachol

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5
Q

lovastatin brand

A

altoprev
mevacor

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6
Q

pitavastatin brand

A

livalo

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7
Q

fluvastatin brand

A

lescol

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8
Q

statin MOA

A

HMG-CoA reductase inhibitors that up-regulate LDL receptors and reduce cholesterol

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9
Q

statin AE

A

serious muscle toxicity (myopathy, rhabdomyolysis)
hepatotoxicity
increased incidence of T2DM

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10
Q

statin CI

A

acute liver disease
unexplained/persistent elevations of serum transaminases
pregnancy
breastfeeding

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11
Q

simvastatin drug-interactions (CI)

A

itraconazole
ketoconazole
posaconazole
erythromycin
clarithromycin
telithromycin
HIV protease inhibitors
nefazodone
gemfibrozil
cyclosporine
danazol

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12
Q

simvastatin dosage considerations

A
  1. dont exceed 10mg simvastatin daily with verapamil or diltiazem
  2. dont exceed 20mg simvastatin daily with amiodarone, amlodipine, or ranolazine
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13
Q

what are the 4 statin monitoring parameters?

A

FLP
LFTs
CK
Hepatic function

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14
Q

how should FLP be monitored in statins?

A

at baseline
4-12 weeks after initiation
then every 3-12 months

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15
Q

how should LFTs be monitored in statins?

A

baseline and repeat as clinically needed
discontinue treatment if LFTs exceed 3x ULN

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16
Q

how should CK be monitored in statins?

A

consider in patients at risk or those experiencing muscle symptoms

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17
Q

how should hepatic function be monitored in statins?

A

consider assessing in patients with signs of hepatotoxicity

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18
Q

ezetimibe brand

A

zetia

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19
Q

zetia MOA

A

cholesterol absorption inhibitor that inhibits NPC1L1

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20
Q

zetia AE

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A

fatigue
diarrhea
GI upset

21
Q

zetia CI

Study These Flashcards
A

same as statins when used concomitantly with them

22
Q

evolocumab brand

23
Q

alirocumab brand

24
Q

MOA of repatha/praluent

Study These Flashcards
A

PCSK-9 inhibitors that promote the degradation of LDL receptors in the liver

25
PCSK9 inhibitors AE
gi upset increased LFTs injection site reaction arthralgia myalgia influenza
26
cholestyramine brand
questran
27
colsevelem brand
welchol
28
colestipol brand
colestid
29
MOA of of the coles
bile acid sequestrants that inhibit bile acid reabsorption and up-regulate LDL receptors
30
bile acid sequestrants AE
constipation bloating N flatulence impaired absorption of fat soluble vitamins (ADEK) hypernatremia hypercholermia GI obstruction
31
cholestyramine CI
complete biliary obstruction
32
colesevelam CI
history of bowel obstruction TG over 500mg/dL history of hypertriglyceridemia-induced pancreatitis
33
bile acid sequestrant counseling
take other medications 1 hour before or 4 hours after BARS may increase TGs
34
fenofibrate brand
tricor
35
gemfibrozil brand
lopid
36
MOA of fibrates
peroxisome proliferator-activated receptor-alpha activators that regulate gene transcription with retinoic acid receptor (RXR)
37
fibrates AE
GI disturbances rash myalgia dizziness gallstones rhabdomyolysis
38
fibrates CI
history of gallbladder disease ESRD dialysis persistent liver disease
39
fibrates counseling
use with caution with statins may potentiate the effects of warfarin, statins, zetia, or sulfonylureas
40
omega-3 fatty acid brand
lovaza
41
icosapent ethyl brand
vascepa
42
icosapent ethyl MOA
omega-3 fatty acid that reduces TGs
43
Omega-3 fatty acids AE
increased LDL levels GI disturbances fishy taste/smell belching
44
niacin brand
niacor
45
niacin MOA
vitamin that can reduce LDL and serum triglyercides at high doses
46
niacin AE
flushing itching tingling of upper body headache hepatotoxicity hyperuricemia hyperglycemia increases LFTs increased levels of statins
47
niacin CI
active hepatic disease significant/unexplained persistent liver transaminase elevations active peptic ulcer arterial hemorrhage
48
niacin counseling
take aspirin 325mg 30 minutes before taking niacin take close to meal times avoid alcohol and hot drinks

Therapeutics 2 - Exam 5 (14 decks)

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