Dysplasia and Oral Cancer- Oral lesions and Therapy Options Flashcards
(50 cards)
What are potentially malignant lesions? What has this terminology replaced and why?
Lesions that may become cancer
Prev. premalignant/precancerous- but this suggests that it will become cancer at some point
-> In PML- most lesions do not change to malignancy
What are the different types of potentially malignant lesions?
White lesions (leukoplakia)
Red lesions (erythroplakia)
Lichen planus
-> Candidal Leukoplakia
-> Chronic Hyperplastic Candidiasis
Oral Submucous Fibrosis
What is Leukoplakia?
(clinical description)
White patch cannot rub off, not attributable to any other disease
-> has higher risk of cancer developing than normal mucosa (but not all white patches have same level of risk)
What is erythroplakia?
Red patch, not attributable to any other disease
-> More commonly associated with malignant change
What does erythema in erythroplakia suggest?
Erythema suggests vascular change consequent to malignancy developing
What should we tell patients about white lesions?
Incidence of cancer is very small
Wide variation in populations- studies have different criteria
Variations also exist in genetics, diet, smoking habits
Be guarded about giving patient information about %chance of malignant changes (make them aware there is a small risk and that lesion should be monitored)
Why is it important not to focus on only red and white lesions when screening for oral cancer?
Most carcinomas arise in clinically normal mucosa
*in UK- in other areas most arise from PMLs
What should be done if a patient presents with a white lesion?
Biopsy to check for dysplasia
What are the features of erythroplakia that mean that referrals are given more credence in OM?
Occurs less frequently
Higher chance of Cancer
Greater dysplasia risk
Which factors in dysplasia are risk of cancer based off?
Cellular atypia
Epithelial architectural organisation- changes in organisation of maturation and normal layering within epithelium
What are the categories in dysplasia?
Low grade
High Grade
Carcinoma-in-situ
Why was moderate dysplasia removed from the categories?
Moderate dysplasia was not well catered for in terms of Tx (difficult choices in whether excision or biopsy was required)
Much clearer distinctions- much clearer guidance for clinician and patient in
What are the cytological features to look out for when carrying out a histological grading of dysplastic tissue?
Abnormal nucleus shape or size
Abnormal cell shape or size
Increased or altered nucleus:cytoplasm ratio
Atypical mitotic features
Nuclear hyperchromatism
Increased number and size of nucleoli
What do the cytological changes during dysplasia represent?
Changes in individual cells reflecting abnormal DNA content in the nucleus, failure to mature/keratinise as normal and increased proliferation
What are the architectural features to look out for when carrying out a histological grading of dysplastic tissue?
Irregular epithelial stratification
Lost/disturbed polarity of basal cells
Drop-shaped rate ridges
Increased and abnormal mitosis
Premature keratinisation in single cells
Abnormal Keratinisation
Keratin pearls in rete ridges
Loss of epthelial cell cohesion/adhesion
What are the typical features of low grade dysplasia?
Tumour originates from squamous epithelium
Architectural change into lower third
Cytological atypia or dysplasia may not be prominent
Considerable amount of keratin production
Evidence of stratification
Well formed basal cell layer surrounding the tumour islands
Tumour islands are usually well defined and are often continuous with the surface epithelium
Invasion pattern with intact large branching rete pegs ‘pushing’ into underlying CT
How is it decided what classification to apply when dysplasia extends into middle third of epithelial layer?
Look at level of atypia to decide if low or high
What are the typical features of high grade dysplasia?
Little resemblance to a normal squamous epithelium
Architectural change upper third
Considerable atypia
Invade in a non-cohesive pattern with fine cords, small islands and single cells infiltrating widely through the CT
Mitotic figures are prominent and many may be abnormal
What is degree of differentiation used to predict?
Prognosis as level correlates with long term survival
What are the features of carcinoma in situ?
Cytologically malignant but not invading
Abnormal architecture:
-> Full thickness (or almost full)
Severe cytological atypia
Mitotic abnormalities frequent
When is the term carcinoma in situ used?
When pathologist strongly suspects carcinoma is present but cannot demonstrate any evidence of invasion through basement membrane
What are histological prognostic factors used for?
Reported to clinicians to help inform management of cancer for MDT
What are the histological prognostic factors associated with poor prognosis?
Pattern of invasion- widely infiltrating small island and single cells have worse prognosis
Depth of invasion- tumours >4mm have greater risk of metastases
Perineural invasion
Invasion of vessels- associated with LN spread (poor prognosis)
What are the genetic and environmental effects on cells that can result in oral cancer?
Can cause cells to have tendency to form unusual divisions ( as they get aggravated by smoking, drinking, other factors)
-> resulting altered cell expression progresses to malignancy and invasion (takes time)
Occurs at different stages in different parts of the mouth depending how environmental stimuli are applied
