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Flashcards in E01L01 Introduction to Pharma Deck (35)
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1

What is the study of drugs or the effects of chemical agents in the function of biologic systems ?

Pharmacology

2

____ is a substance that brings about a CHANGE in BIOLOGIC FUNCTION through its CHEMICAL ACTIONS

Drug

3

_______ ____________ is concerned with the use of chemicals in the prevention, diagnosis and treatment of disease

Medical Pharmacology

4

What do you call the science of poisons or the study of undesirable effects of chemicals on living systems?

Toxicology

5

What Denotes the actions of the drug on the body (i.e what the drug does to the body)

Pharmacodynamics

6

What Describes the actions of biological systems on drugs? (i.e. what the body does to the drug)

Pharmacokinetics

7

Who is the Father of Pharmacology?

Oswald Schmiedeberg

8

Who isolated the first pure glycoside in crystal form from foxglove, which he called “digitoxin” ?

Oswald Schmiedeberg

9

Who isolated a much-purified material he called “digitalin” from foxglove in 1869 6 years after Oswald Schmiedeberg's "digitoxin"?

Nativelle

10

Boehringer Mannheim (1888), F. Kraft (1912) discovered _______

other glycosides of foxglove

11

Who said that said that "Facts and facts alone are the basis of science“ and wrote the “Formulary for the preparation and mode of employing several new remedies” ?

Francois Magendie

12

Who studied curare and carbon monoxide gas on animals

Claude Bernard

13

Who established the first laboratory for experimental pharmacology in his basement, later moved to the Anatomy Theatre of University of Dorpat (now Tartu University in Estonia)?

Rudolph Buchheim

14

Who coined coined ‘chemotherapy’, started era of antimicrobial therapy?

Paul Erlich

15

Who introduced chemical receptor theory & “receptive substance”?

John Newport Langley

16

Who identified acetylcholine as possible neurotransmitter?

Sir Henry Hallet Dale

17

Who is Schmiedeberg’s student, trained many US pharmacologists and is the Father of American Pharmacology?

John Jacob Abel

18

Who is the Father of Philippine Pharmacology?

Dr. Daniel de la Paz

19

____________ deals with the use of chemotherapeutic agents to inhibit or destroy invading microbes, parasites or cancer cells with minimal effect on healthy living tissues.

Chemotherapy

20

________________ deals with genetically mediated variations in drug responses.

Pharmacogenetics

21

________ ____________ is a branch of pharmacology that deals with the pharmacological effects of drugs in man.

Clinical Pharmacology

22

_______________ deals with the development of new drug delivery systems and new dosage forms.

Biopharmaceutics

23

________________ is the use of genetic information to guide the choice of drug therapy on an individual basis.

Pharmacogenomics

24

____________________ is the study of drug effects at the population level, and helps in regulation of drugs.

Pharmacoepidemiology

25

AGONIST : active conformation of the receptor:: ________: inactive conformation of the receptor

ANTAGONIST

26

What is the receptor target of digoxin?

Na-K-ATPase

27

Which of the following statements is true about digitoxin?
A. Stimulates renin in the kidney
B. Decreases entrance of Na+ into the cell
C. Increases renal tubular reabsorption of Na+
D. Increase sympathetic outflow from CNS

B. Decreases entrance of Na+ into the cell

28

Side effects of digitalis include
A. heart arrythmia
B. GIT anorexia, nausea, vomiting, diarrhea
C. Vagal and chemoreceptor stimulation
D. Disorientation hallucination, visual disturbances
E. AOTA

E

29

Therapeutic range of digitoxin

therapeutic range: 0.5- 2 ng/ml

30

Digoxin oral bioavailability

75%

31

Digoxin Volume of Distribution

6.3L/kg

32

Digoxin Half-life

40hrs

33

Digoxin Plasma Protein Binding

20-40%

34

Digoxin Percent Metabolized

40%

35

True about rational drug use

A. Optimization of THERAPEUTIC EFFICACY
B. AVOIDANCE and PREVENTION of toxicity
C. SOCIALLY-RESPONSIBLE prescribing behavior
D. AOTA

D