E01L02 Mechanisms of Drug Action Flashcards Preview

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Flashcards in E01L02 Mechanisms of Drug Action Deck (26)
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1

_______-____-_____ _____ implies that # of receptors may limit max effect of drug

sigmoid-dose-response curve

2

True about Receptor-mediated drug action except
A. All receptors are protein
B. Specificity is due to shape and electrical charge via structural diversity
C. has 2 major domains - receptor and effector
D. Can be identified by drug binding and gene sequencing

A

3

[Type of receptor] Neurotransmitters, autocoids, hormones

Regulatory Proteins

4

[Type of receptor] inhibited by drug binding

Enzymes

5

[Type of receptor] e.g. Na-K-ATPase

Transport

6

[Type of receptor] e.g. tubulin - receptor for colchines

Sturctural

7

IUPHAR stands for

International Union of Pharmacology

8

Ach, Serotonin, GABA, glutamate act on
A. Ligand Gated Ion Channels
B. Voltage Gated Ion Channels
C. G-Protein coupled receptors
D. Enzyme-linked receptors

A

9

What is common about Phenytoin, Lamotrigine and Valporate?

Inhibit Na+ channels therefore are used as anticonvulsants

10

What is verapamil for?

Inhibit voltage-gated Ca2+ channels at vascular smooth muscle, decrease BP antiarrhythmic

11

___________ Receptor - no ion but linked to G-receptor

Metabotropic

12

Which of the following statements is false?
A. Gαs open ion channels (Ca2+) in myocardium and skeletal muscle
B. Gi open K+ Channel in heart and smooth muscles
C. Gαs close neuronal Ca2+ channel
D. Gi close neuronal Ca2+ channel

C

13

Physiological ligand for receptor for tyrosine kinase are the following except
A. Insulin
B. PDGF
C. EGF
D. VEGF
E. Interleukin

E

14

Effector of Receptors for tyrosine kinase

SH2 domain

15

Herceptin and Imatinib target

Receptor for tyrosine kinase

16

Interleukin and other cytokines act on

Cytokine receptors

17

Effector of cytokine receptor

Jak/STAT

18

Effetor of guanylylcyclase

cGMP

19

Physiological ligand of guanylyl cyclase

Natriuretic peptides

20

Example drug that targets guanylyl cyclase

Nesiritide

21

Purpose of phsophorylation include the following EXCEPT
A. Amplification
B. Flexible regulation
C. A only
D. Both A and B

D

22

Non-receptor mediated drug action; chelates blood thus used in treating lead poisoning

EDTA

23

Non-receptor mediated drug action; treat fibrotic skin disorder

PABA

24

What is the non-receptor mediated action of KMnO4?

antiseptic

25

What is the non-receptor mediated action of Mannitol?

Osmotic disorder

26

Describe tachyplaxis

diminution of receptor response due to frequent exposure to agonists