Ear, Nose, Throat

Question 1

Sofradex

Answer 1

1. Dexamethasone, framycetin and gramicidin
2. Otitis externa
   Accepted - Chronic suppurative otitis media
   Discharging tympanostomy tubes
   (Ear infections)
3. Total tx duration for otitis externa should not exceed 2 weeks.
   Adult, child, 3 ear drops 3 or 4 times daily until a few days after symptoms have cleared.
4. Precautions
   Perforated eardrum, tympanostomy tube—risk of inner ear damage is increased by the aminoglycoside (framycetin) but remains low; if use is unavoidable, limit treatment to 5–10 days (contraindicated by manufacturer).

Precautions from Corticosteroids with anti-infectives
Pregnancy
Safe to use.

Breastfeeding
Safe to use.

Ear drops containing ciprofloxacin are preferred if eardrum perforation cannot be excluded

5. If you develop ringing in the ears, hearing loss or difficulty with balance, stop using this medication and tell your doctor.
   Common (>1%)
   allergic dermatitis after prolonged use, particularly with neomycin and clioquinol

Infrequent (0.1–1%)
fungal overgrowth (with prolonged use)

Rare (<0.1%)
inner ear damage (with products containing framycetin or neomycin)