What are anorexia and obesity related to?
What part of the brain is anorexia?
: lateral hypothalamic syndrome
What part of the brain is obesity linked?
ventromedial hypothalamic syndrome
What is the response to elevated leptin levels?
Activation of arcuate neurons that release αMSH and CART peptides Anorectic peptides- diminish appetite
Where does the activated arcuate neurons project and release alphaMSH and CART peptides?
Project to regions that orchestrate coordinated response of humoral, visceromotor, and somatic responses Paraventricular nucleus (humoral response) Intermediolateral gray matter of spinal cord Lateral hypothalamus
What is the response to decreased leptin levels?
Activation of arcuate neurons that release NPY and AgRP (Leptin inhibits these cells)
What is the effect of activation of arcuate neurons that release NPY and AgRP in response to decreased leptin levels?
•Effects on energy balance: Opposite to the effects of αMSH and CART
•Orexigenic peptides– increase appetite
•NPY and AgRP inhibit secretion of TSH and ACTH
•Activate parasympathetic division of ANS
•Stimulate feeding behavior