EB

Question 1

What does EB stand for

Answer 1

Epidermolysis bullusa

Question 2

What type of alleles cause severe EB

Answer 2

2 recessive

Question 3

What type of alleles cause mild EB

Answer 3

1 dominant

Question 4

Which set of parents may produce an offspring with severe EB

Answer 4

Ee x Ee

Question 5

Describe stages of protein transcription

Answer 5

DNA unzips by DNA helicase
free RNA nucleotides line up opposite the exposed bases using complimentary base pair rule
RNA polymerase join the nucleotide to make mRNA
MRNA leaves the nucleus

Question 6

Outline 4 principles of wound care for EB

Answer 6

Cleaning wound
Maintaining most environment
Protecting wound
Promoting optimal healing conditions

Question 7

Suggest 4 strategies to avoid infection for EB

Answer 7

Using disinfectants
Proper wound dressing techniques
Regular monitoring and assessment of wound
Hygiene practices

Question 8

3 advantages of topical and oral treatment for EB

Answer 8

Topical
- reduce side effects
- easy to apply
- strengthen integrity of epidermis and dermis

Oral
- provide relief using pain killers
- wider availability
- easy to administer -

Question 9

3 disadvantages of topical and oral treatment for EB

Answer 9

Topical
- not effective
- potential irritation
- limited availability

Oral
- side effects
- drug interactions
- lead to dependence

Question 10

What type of research method would have been used to research the side effects of cannabinoids

Answer 10

Questionnaire
Quantitive and qualitative research

Question 11

Describe the spirometry test for lung function, what is measured and the FEV1/FVC ratio

Answer 11

1. Patient it on chair and clip placed on nose to keep nostril closed
2. Take deep breath + exhale forcefully and quickly in mouthpiece
3. Repeat 3 times for average
4. FVC = total amount of air you exhale after taking deep breathe
5. FEV1 = amount of air you can exhale in 1 second
6. FEV1/FVC ratio = % of lung capacity that you exhale in 1 second

Question 12

Stages of biopsy

Answer 12

Specimen cut
Infiltrate with alcohol
Impregnated with paraffin wax
Cut into sections
Stain
View under microscope

Question 13

What happens to the lining of trachea with a person with EB

Answer 13

Becomes blistered and inflamed

Question 14

Describe 4 protein structures

Answer 14

Primary - sequence of amino acids
Secondary - folding into alpha helix / beta pleated
Tertiary - 3D shape formed
Quaternary - joining of polypeptides

Question 15

Bonds formed for each protein structure

Answer 15

Primary - peptide
Secondary - hydrogen
Tertiary - ionic
Quaternary - ionic, hydrogen, disulphide, peptide