EBM

Question 1

define EBM

Answer 1

the conscientious explicit and judicious use of current best evidence in making decisions about the care of individual patients

Question 2

limitations of EBM

Answer 2

practical limitations:
financing of research
publication bias
under representation of trial patients
focus on statistical as opposed to clinical significance
reporting bias

philosophical limitations:
socioeconomic support

ethical limitations:
patient values

Question 3

financing of research

Answer 3

study which compared entresto (angiotensin receptor-neprilysin inhibitor) with enalapril in patients with HFref

they found that entresto performed much better than enalapril regarding mortality and hospitalisation

but this study was funded by Novartis which introduced Entresto - publication bias
- only publishing positive outcomes

Question 4

example of publication bias

Answer 4

prozac
- negative outcomes wasn’t being reported