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Flashcards in Ectoparasiticides Deck (10)
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1

What is the only FDA approved treatment for demodicosis?

Amitraz
- Amitraz suspension dip on weekly basis (wear protective clothing)
- also for control of mites and ticks

2

Where does Amitraz act?

Activation of octopamine receptors
- inhibitory, leads to decrease in cAMP and intracellular calcium

3

Adverse Reactions w/ Amitraz

CNS depression, bradycardia, GI atony, colic
- DUE TO ACTIVATION OF ALPHA-2 ADRENERGIC RECEPTORS (similar to what happens w/ Xylazine)
- treatment w/ an alpha-2 antagonist (Yohimbine)

4

Nicotinic Receptor Agonists
- Imidacloprid, Nitenpyram, Dinotefuran

- can be used as fleacides
- highly selective for insect receptors, and have minimal effect on mammal nicotinic receptors

5

Which nicotinic receptor agonist has the greatest affinity for insect receptors?

Nitenpyram

6

Which nicotinic receptor agonist is stored for 30 days in sebaceous glands?

Imidacloprid (Advantage RR)
- it's a spot-on once a month

7

Nitenpyram

Insect nicotinic receptor agonist
- high selectivity for insect receptors
- ORAL ----> rapid GI absorption, urinary excretion
- kills 95% of fleas within 5 hrs; LASTS 1-2 days
- SAFEST fleacide w/ shortest duration
- CAN BE USED IN NEWBORN ANIMALS

8

When should Nitenpyram be used?

Use to treat infested newborn animals, or use in boarding situations where fleas need to be killed quickly

9

Why use Nitenpyram + Lufenuron?

Lufenuron will kill immature fleas, Nitenpyram will kill adult fleas

10

Which fleacide works both on chloride channels and as nicotinic receptor agonist?

Spinosad
- a macrocyclic lactone (works on Chloride channels) but also is a nicotinic receptor agonist (influx of sodium) (it works on different nicotinic receptors than the neonicotinoids)
- So, technically spinosad causes both hyperpolarization and depolarization ======> PROBLEM!??