Flashcards in Ectoparasiticides Deck (10)
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1
What is the only FDA approved treatment for demodicosis?
Amitraz
- Amitraz suspension dip on weekly basis (wear protective clothing)
- also for control of mites and ticks
2
Where does Amitraz act?
Activation of octopamine receptors
- inhibitory, leads to decrease in cAMP and intracellular calcium
3
Adverse Reactions w/ Amitraz
CNS depression, bradycardia, GI atony, colic
- DUE TO ACTIVATION OF ALPHA-2 ADRENERGIC RECEPTORS (similar to what happens w/ Xylazine)
- treatment w/ an alpha-2 antagonist (Yohimbine)
4
Nicotinic Receptor Agonists
- Imidacloprid, Nitenpyram, Dinotefuran
- can be used as fleacides
- highly selective for insect receptors, and have minimal effect on mammal nicotinic receptors
5
Which nicotinic receptor agonist has the greatest affinity for insect receptors?
Nitenpyram
6
Which nicotinic receptor agonist is stored for 30 days in sebaceous glands?
Imidacloprid (Advantage RR)
- it's a spot-on once a month
7
Nitenpyram
Insect nicotinic receptor agonist
- high selectivity for insect receptors
- ORAL ----> rapid GI absorption, urinary excretion
- kills 95% of fleas within 5 hrs; LASTS 1-2 days
- SAFEST fleacide w/ shortest duration
- CAN BE USED IN NEWBORN ANIMALS
8
When should Nitenpyram be used?
Use to treat infested newborn animals, or use in boarding situations where fleas need to be killed quickly
9
Why use Nitenpyram + Lufenuron?
Lufenuron will kill immature fleas, Nitenpyram will kill adult fleas
10
