ED 3 Flashcards Preview

Stage 2, Cycle 2 - Extemporaneous Dispensing > ED 3 > Flashcards

Flashcards in ED 3 Deck (29):
1

Define 'Solutions'

Homogenous liquid preparations containing one or
more dissolved substances

2

What factors should be considered when preparing a solution ?

- Solubility of solid constituents
- Which solvents to use ?
- Temperature
- pH (affects stability of final product)
- Colourings, flavourings and preservatives

3

During preparation of a solution, in what order do you add the soluble ingredients ?

Ascending order (least to most soluble)

4

Define 'Suspensions'

Preparations where one or more active constituent is suspended in the disperse phase

5

Some formulas may or may not contain suspending agents. TRUE or FALSE

TRUE

6

Why is it important for non-soluble constituents to be re-suspended for long enough ?

Allows patient to measure an accurate dose

7

Give for examples of Suspending agents

1) Tragacanth BP
2) Compound Tragacanth Powder BP
3) Xanthan gum
4) Methylcellulose

8

What is Compound Tragacanth Powder BP made out of ?

- Acacia BP 20%
- Tragacanth BP 15%
- Starch BP 20%
- Sucrose BP 45%

9

About how many %w/v Tragacanth BP is used in suspensions ?

0.2%

10

About how many %w/v Compound Tragacanth Powder BP is used in suspensions ?

2%

11

Compound Tragacanth Powder BP is said to be too sticky for external products. TRUE or FALSE

TRUE

12

About how many %w/v Xanthan gum is used in suspensions ?

2%

13

About how many %w/v Methylcellulose is used in suspensions ?

b/wn 0.5 - 2%

14

Is Xanthan gum highly soluble in hot or cold water ?

Cold water

15

Methylcellulose is a semi-synthetic polysaccharide. TRUE or FALSE

TRUE

16

Name 4 other types of suspending agents

1) Guar gum
2) Sodium alginate
3) Hydromethylcellulose
4) Sodium carboxymethylcellulose

17

How many weeks expiry do 'Freshly prepared' solutions and suspensions have ?

Two weeks

18

How many weeks expiry do 'Recently prepared' solutions and suspensions have ?

4 weeks

19

When should 'freshly prepared' solutions and suspensions be prepared ? (according to BP 2018 recommendations)

'No more than 24 hrs before it is issued for use'

20

When is deterioration likely to occur for 'recently prepared' solns and suspensions ? (According to BP 2018 recommendations) ?

Likely to occur if preparation is stored for longer than 4 weeks at 15 - 25 degrees celcius

21

Define 'Trituration'

- Incorporation of finely divided insoluble powders or liquids into a base

22

Define 'Levigation'

- Incorporation of coarse insoluble powders into a base

23

Define 'Fusion'

- Melting of bases before the addition of other ingredients

24

During 'Fusion' process, why does the melting points of ingredients need to be known ?

Because you start with the ingredient with the highest melting point

25

What is the standard expiry for Creams and Ointments

3 months from date of manufacture

26

Why do creams/ointments have a long expiry ?

Because the cream/ointment bases contain
preservatives in their formulae

27

What is the expiry for Diluted creams ?

1 month from date of manufacture

28

Why do diluted creams have shorter expiry ?

Because creams are generally diluted with aqueous
cream and the aqueous environment is more susceptible to bacterial growth

29

Do diluted ointments also have a shorter expiry like that of diluted creams ?. YES or NO

NO