Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

V - KCU - HDM (T2) - OMS1 > Effector Mechanisims Of Humoral Immunity (Ch. 8) > Flashcards

Effector Mechanisims Of Humoral Immunity (Ch. 8) Flashcards

1
Q

How do vaccines work

A

By stimulating ab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does TNF do

A

Stimulates inflammation, coag., and apoptosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the function of IgG

A

Opsonization of Ag for phagocytosis

Act. Of compliment pathway

ADCC by NK cells

Feedback inhibition of B Cell activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the function of IgM

A

Activation of classical pathway complement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the function of IgA

A

Mucosal immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the function of IgE

A

Eos and mast cell mediated defense against parasites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the role of FCRN and how does it work

A

Keeps IgG alive for a long time

Binds to endosomes with IgG/Ag complex
Separates IgG from Ag and transports IgG back to surface of the cell.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What IgG in humans binds to macro. And neutrophils to ingest microbes and what do they bind to?

A

IgG1 and IgG3 which bind to FcyR1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where does Ab mediated phagocytosis (using IgG1 and IgG3) usually occur

A

In the spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the function of FcyR1

A

Ab mediated phagocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the function of FcyRIIB

A

Feed back inhibition of B cells, attenuation of inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the function of FcyRIIIA

A

ADCC in NK cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the function of FceR1

A

Activation of mast cells and eosinophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Pooled IgG from healthy pt. Will do what

A

Treat inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What cells express FcyRIIIA and what do they do

A

NK cells express this, allows NK cells to bind to IgG on microbes and activate a release of granules to kill microbe

Called Ab-dependent cellular cytoxicity (ADCC)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How does Ige kill worms

A

Binds to them and attracts Eos to them to bind through FceRI

Th-2 Cells must also secrete IL-5 to activate Eos.

17
Q

What is the function of C3b

A

Opsonin of microbes which allows them to be destroyed by phagocytes after being recognized by CR1

18
Q

What is the function of C3a

A

Inflammation

19
Q

What is the function of C1 (and its parts)

A

Overall initiates the classical pathway

C1q binds to the Fc portion of IgG, C1r and C1s lead to C4 and C2 activation

20
Q

What is the function of C4a

A

Stimulates inflammation

21
Q

What does Factor D do?

A

In alternative pathway, breaks down Factor B into Bb which then attaches to C3b to become C3Bb

22
Q

What is C3 convertase

A

C3bBb

23
Q

What does C3bBb do next in alt. Pathway?

A

Binds to one more C3b and makes C3bBb3b which is now the C5 convertase and continues the pathway

24
Q

What does C5a do

A

Inflammation

25
Q

Which C actually opens up the cell for lysis

A

C9

26
Q

B-cells recognize what opsonin with what receptor

A

Recognize C3d with CR2 (CD 21)

27
Q

Phagocytes recognize what opsonin with what receptor

A

C3b with CR 1 (CD35)

28
Q

Compliment proteins are also recognized by what in germinal centers

A

FDCs which allow for increased affinity B cells

29
Q

What does C1 INH do

A

Blocks C1r2s2 in classical comp. pathway

30
Q

What does DAF do

A

DAF along with CR1 remove either Bb (in alt. Pathway) or C4b (in classical pathway)

This stops the formation of C3 convertase

31
Q

What does MCP (CD49) do

A

Along with CR1 act as cofactors of Factor 1 which destroys C3b

32
Q

What does C4BP do

A

Acts as a cofactors for Factor I

Causes dissociation of classical pathway C3 convertase subunits

33
Q

What does CD 59 do

A

Blocks C9 binding and prevents formation of the MAC

34
Q

What is caused by a deficiency of C1 INH

A

Hereditary angioedema due to increased C1 and increased inflammation from it

35
Q

What is paroxysmal nocturnal hemoglobinuria

A

An acquired deficiency of HSC of a membrane anchor of DAF and CD 59 which leads to unregulated comp. act. And RBC lysis

36
Q

What causes a heavy-chain switch to IgA

A

TGF-B

37
Q

What transports IgA into the lumen

A

Poly-Ig Receptor, also prevents it from being destroyed

V - KCU - HDM (T2) - OMS1 (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions