effector T cells

Question 1

TH1 cells differentiation

Answer 1

induced by: IL-12, IFN-gamma
master transcription factor= Tbet
produces: IFN-gamma, TNF-alpha, IL-2

Question 2

TH1 cells effector function

Answer 2

MACROPHAGE ACTIVATION
killing, proliferation of other t cells, endothelial activation, chemotaxis

Question 3

TH2 cells differentiation

Answer 3

induced by: IL-4
master transcription factor= GATA3
produces: IL-4, IL-5, IL-13

Question 4

effector function of TH2

Answer 4

epithelial turnover
tissue repair
mast cell recruitment
eosinophil recruitment

Question 5

T17 differentiation

Answer 5

induced by: TGF-beta, IL-6
master transcription factor= RORgammat
produces: IL-17, IL-22

Question 6

EFFECTOR FUNCTIONs of TH17

Answer 6

epithelial protection, turnover, neutrophil production, induce chemotaxis in stromal cells and epithelial cells

Question 7

innate subsets that mirror t cell functions

Answer 7

all have the same transcription factor
TH1 = ILC1
TH2 = ILC2
TH17 = ILC3