immune memory

Question 1

T cell memory theory

Answer 1

precursor model
asymmetric fate model
decreasing potential model
signal strength model

Question 2

What receptors do memory cell precursors have?

Answer 2

IL-7R

Question 3

What receptors do effector cell precursors have?

Answer 3

KDRG1

Question 4

Central TM

Answer 4

expresses: CD62L, CCR7
Are in: lymphoid tissues and blood
functional properties: proliferative potential, needs IL-2

Question 5

Effector TM

Answer 5

expresses: CCR5
Are in: non-lymphoid tissues and blood
- lose tissue specificity after initial infection
functional properties: little proliferative potential, doesn’t need IL-2, high effector function

Question 6

Tissue-resident TM

Answer 6

expresses: CD69
Are in: tissues of previous infection
functional properties: proliferative potential, high effector function NO RECIRCULATION!

Question 7

Requirements of naïve t cells

Answer 7

MHC self molecules
IL-7

Question 8

Requirements of memory t cells

Answer 8

no MHC self
IL-15 (needed for circulation)
IL-7