Elimination problem Flashcards

Congenital disorders, vomiting, constipation, diarrhoea

1
Q

What is oesophageal atresia?

A

Blind ending oesophagus

Often occurs in conjunction with a tracheal oesophageal fistula (88%)

Occurs when there is failed division of the foregut into the trachea and oesophagus at 6 weeks gestation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How many births does oesophageal atresia/ tracheal oesophageal fistula affect?

A

1 in 3500

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Clinical features of oesophageal atresia/ tracheal oesophageal fistula

A

May be suspected antenatally: causes polyhydramnios

Neonates will have saliva pooling in mouth with bubbles in nose

Choking/ dusky episodes when feeding as milk spills into lung

Narrow fistula may be diagnosed in older child with recurrent chest infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is a diagnosis of oesophageal atresia/ TO fistula made?

A

Baby tries to feed: chokes or vomits

Made postnatally if NG tube cannot be placed

In isolated atresia there is no stomach bubble present on CXR - presence of bubble suggests there is also a TO fistula

Imaging used to diagnose: CXR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Management of oesophageal atresia/ TO fistula

A

Nil by mouth until surgery (within 24hrs)

Suction to remove saliva and prevent aspiration

Prognosis good, reflux can occur in later life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

When do congenital anomalies of the GI tract/ liver occur?

A

During 1st trimester when separation of the foregut into the GI tract and resp system occurs

Separation usually occurs around week 6-10

Often diagnosed on antenatal scans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Difference between gastrochisis and exomphalos

A

Both are defects of the anterior abdominal wall

Gastrochisis = bowels escape to the right of the umbilicus and there is no covering of the bowel (escape the G)

Exomphalos: bowels herniate through the umbilicus, liver can also herniate, contents of the hernia are covered in perioteneum (can’t escape the O so are sealed within membrane)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is gastrochisis?

A

Congenital anomaly of the gut

5/10,000 live births

Intestines herniate to the right of the umbilicus - not covered by peritoneum

Usually diagnosed @ 18-20 week scan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Risk factors for gastrochisis

A

Young maternal age

Smoking

Drug use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Management of gastrochisis

A

Immediate: cover bowel in bag/ clingfilm to protect

Long-term: surgery

Bowel is surrounded by a doughnut shaped support to prevent vascular occlusion

Good prognosis but some babies have prolonged feeding difficulty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is exomphalos?

A

Affects 3/10,000

Bowel herniates through umbilicus, liver can also herniate

Contents are covered in peritoneum

Risk factors: maternal drug use and smoking

Common to find associated conditions: trisomies, Beckwith-Weidemann syndrome

Management = surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is Beckwith Weidemann syndrome?

A

Condition which affects many parts of the body, classified as an overgrowth disorder - associated with presence of exomphalos as the gut grows too large for the abdomen

Children tend to grow larger than their peers but growth slows around age 8

Increased risk of cancer + non-cancerous tumours

Normal life expectancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Discuss malrotation of the gut

A

Bowel is fixed in an abnormal position in the abdomen due to abnormal rotation of midgut

Small bowel sticks to posterior abdominal wall

1/2500 babies

Can be asymptomatic but can lead to volvulus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is volvulus?

A

Where intestine twists around itself and mesentry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How do patients with malrotation present?

A

Can be asymptomatic

If volvulus has occurred: bilious vomiting, intermittent abdo pain

Upper GI contrast studies will show duodeojejunal flexure in abnormal position

Surgical emergency as volvulus can lead to necrotic bowel if the blood supply from mesentery is occluded

Bowel is fixated to correct position to remove risk of volvulus or other complications

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Hirschsprung’s disease

A

Neural crest cells fail to migrate to bowel muscle

1/5000

Parasympathetic innervation of the distal colon is poor so the affected segment is always contracted which causes obstruction and gross dilation of the section above the affected area

Length of bowel affected varies: always affects internal anal sphincter, often involves sigmoid colon and 20% involve descending colon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Clinical features of Hirschsprung’s

A

Newborn who has failed to pass meconium within 48hrs

Distended abdomen

Vomiting

PR examination causes explosive passage of stool

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Diagnosis of Hirschsprung’s

A

Abdo x-ray shows dilated loops of bowel

Rectal biopsy shows lack of ganglionic nerve cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Management of Hirschsprung’s

A

Initial: rectal washout/ bowel irrigation

Definitive: surgery to remove affected segment of colon and anastamosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Intestinal atresia

A

Blind ending passage due to abnormal embryology

Most common = duodenal atresia (30% associated with Down’s)

Causes biliosu vomiting if its after the hepatopancreatic duct because bile can’t go anywhere apart from up

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How does intestinal atresia present?

A

Commonly duodenal atresia

Bilious vomiting if after the hepatopancreatic duct

AXR: dilated loops of bowel proximal to atresia + classic double bubble (can also be seen on USS)

Double bubble occurs because there is dilation of the stomach and proximal duodenum due to atresia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is biliary atresia?

A

Rare

Atresia of the common bile ducts or hepatic ducts

Bile is made but cannot reach small intestine so causes inflammation of the ducts and the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

How does biliary atresia present?

A

Prolonged jaundice

Pale stool

Dark urine

Poor weight gain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

How is biliary atresia diagnosed?

A

Bloods: raised conjugated bilirubin + deranged LFTs

USS: absence of biliary tree

Radioisotope scan will show absent excretion of radiolabelled bile from the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
How is biliary atresia managed?
Hepato-portoenterostomy is performed Aim is to enable bile to flow into small intestine Not curative - many children need liver transplant
26
Approach to vomiting in a child
27
What are the most common causes of vomiting in children?
1. Intestinal causes: reflux, pyloric stenosis, malrotation and obstruction, cow's milk protein allergy 2. Infection: UTIs can cause persistent vomiting in children 3. Cerebral disorders: raised ICP 4. Renal: failure, tubular acidosis 5. Metabolic disorders: adrenal failure
28
Causes of bilious vomiting in a baby?
Blockage: Malrotation Intestinal atresia (commonly duodenal) Meconium ileus
29
First thing to ascertain when a baby presents with vomiting
Bilious or non bilious
30
When baby presents with non-bilious vomiting, first thing to consider?
Projectile or not?
31
Non-bilious, projectile vomiting?
Pyloric stenosis
32
Baby has non-projectile vomiting and they are unwell - what are the possible diagnoses?
**Infection** If they also have diarrhoea: probably gastroenteritis If they do not have diarrhoea: possibly sepsis or meningitis
33
Baby has non-projectile vomiting, non bilious. What could it be?
No signs of raised ICP: reflux Signs of raised ICP: space occupying lesion or hydrocephalus
34
Gastro-oesophageal reflux in a child
Non-forceful regurg of contents up the oesophagus, sometimes into mouth **- Babies have weak LO sphincters, have a liquid diet and are often supine = recipe for reflux** Physiological in infants but can be troublesome and cause FTT More common in premature babies and those with neuro-developmental impairment, less common in older children and teenagers
35
Symptoms of gastro-oesophageal reflux
Asymptomatic in most Discomft: draing up legs during or after feeds, arched back, crying Large vomits after feeding FTT if severe Common source of anxiety in parents
36
Management of gastro-reflux in a child?
Reassurance is often all that is needed Investigate if patient is not growing Overfeeding is a common problem so ascertain how much child is having If patient has neuro-developmental impairment they are at risk of aspiration so surgery may be needed 90% cases resolve by 1 year * Advise regarding position during feeds - 30 degree head-up * infants should sleep on their backs as per standard guidance to reduce the risk of cot death * ensure infant is not being overfed (as per their weight) and consider a trial of smaller and more frequent feeds * a trial of thickened formula (for example, containing rice starch, cornstarch, locust bean gum or carob bean gum) * a trial of alginate therapy e.g. Gaviscon. Alginates should not be used at the same time as thickening agents * * NICE do not recommend a proton pump inhibitor (PPI) to treat overt regurgitation in infants and children occurring as an isolated symptom. A trial of one of these agents should be considered if 1 or more of the following apply: * Unexplained feeding difficulties (for example, refusing feeds, gagging or choking) * distressed behaviour * faltering growth * Ranitidine was previously used as an alternative to a PPI but was withdrawn from the market in 2020 as small amounts of the carcinogen N-nitrosodimethylamine (NDMA) were discovered in products from a number of manufacturers. * prokinetic agents e.g. metoclopramide should only be used with specialist advic *
37
Overfeeding babies
More common with bottle fed babies as its more difficult for baby to control milk flow Causes wind, cramps, watery poo, foul smelling poo, sleep problems and irritability
38
Pyloric stenosis
Male babies typically (4:1 M:F), hypertrophy of pyloric muscle 2-4/1000 live births **Typical presentation:** 3-8 week old with projectile vomiting **Examination:** hungry, dehydrated, poor weight gain, ripples across abdomen **Diagnosis:** test feed causes projectile vomiting and peristalsis visible on abdomen, small lump palpable, bloods show hypochloraemic, hypokalaemic alkalosis due to vomiting, USS confirms diagnosis - shows thickened pylorus **Management:** correct electrolytes, surgery - Ramstedt's pyloromyotomy (pylorus is cut to widen abnormality) **Good prognosis**, can reintroduce milk almost immediately
39
Causes of abdominal pain in chidren
Appendicitis, intusussception, Meckel's diverticulum, Mesenteric adenitis, constipation
40
What symptoms of abdominal pain in a child would warrant further investigation?
Severe pain Pain lasting a long time Recurrent pain
41
How can paediatric abdo pain be categorised?
**Surgical causes:** appendicitis, intussusception, hernia, testicular torsion **Infective:** gastroenteritis, lower lobe pneumonia, UTI, mesenteric adenitis **Non-infective:** constipation, coeliac disease, IBD, DKA, peptic ulcer, functional/ 'non-organic'
42
Appendicitis
Lumen of appendix occluded by faecoliths Affects any age, 10% of all people during lifetime but most common during teens **Presentation:** decreased appetite, central abdo pain which migrates to RIF, vomiting, fever (LESS SPECIFIC SYMPTOMS IN YOUNGER CHILDREN) **Examination:** guarding and tenderness over RIF, rebound tenderness, rigidity associated with peritonitis if appendix has perforated **Diagnosis:** waised WCC and CRP, USS showing inflamed appendix **Management:** appendicectomy
43
Intussusception
Invagination of bowel like a telescope, most commonly at terminal ileum which invaginates into caecum & takes mesentery with it Pathophysiology: causes oedema, ischaemia and necrosis + perforation **Presentation:** intermittent pain, drawing up legs, inconsolable crying, vomiting and pallor, palpable sausage-shaped mass, redcurrant jelly blood = late sign ⚠️ **Investigations:** USS shows target sign **Management:** reduce by air enema (works in 70%), 30% need surgery Air can cause or reveal perforation: surgery required Recurs in 5% If symptoms present for 24hrs+ or if suspicion of perforation surgery is needed due to high risk of necrosis
44
Meckel's diverticulum
Remnant of vitello-intestinal duct which connects yolk sac and gut during embryonic development Affects 2% population - only 5% symptomatic as bleeding occurs within diverticulum **Presentation:** fresh bleeding from rectum, melaena, low Hb, microcytic anaemia due to chronic bleeding, abdo pain, tenderness near umbilicus **Rule of 2s** - M:F 2:1 - 2yrs old = most common age - 2 feet from ileocaecal valve - 2 inches long - 2 cm wide Diagnosis: USS or AXR may show blockage, radioisotope scan (Meckel's scan) comfirms, faecal sample showing presence of blood, laparotomy Management: surgery
45
Mesenteric adenitis
Inflammation of the mesenteric LNs - common cause of abdo pain in children Nodes enlerge due to infection (usually viral e.g. URTI) Self-limiting, give pain relief Pain can mimic appendicitis
46
Non-organic abdominal pain in a child
Functional abdo pain Poorly localised/ central abdo pain but all investgations are normal Normal growth Management: coping strategies
47
Abdominal migraine
Poorly localised abdo pain, may be associated with vomiting, family hx of migraines Pain usually resolves as child gets older but many develop migraines later on
48
Consitpation in children: overview
Affects up to 30% of children Often due to lack of fibre **Presentation:** abdo pain, poor appetite, infrequent bowel opening, straining, hard & small stool \>\> Pain can lead to child not wanting to use toilet \>\> makes situation worse Soiling is common as liquid overflow bypasses blockage **Diagnosis:** clinical, important to rule out FTT and underlying disease Examination: mass in abdomen commonly LIF, inspect anal area for fissures, don't do PR if suspecting constipation, neuro examination of legs to rule out spinal pathology **Management:** advice re diet and fluid intake, laxatives/ laxitive disimpaction regimen before staring maintenance therapy
49
What features of constipation might suggest underlying disease?
Present since birth: may suggest congenital anomaly Delayed passage of meconium: Hirschsprung's or CF FTT: coeliac disease, hypothyroidism, CF Abnormal spine or weakness in legs: spinal abnormality e.g. spina bifida
50
What might prompt investigation for hypothyroidism if child presents with constipation?
Lack of energy, feeling the cold, unusual weight gain
51
Types of laxatives
Stimulant: senna + sodium picosulphate Osmotic: lactulose Macrogols: bulk the stool e.g. polyethylene glycol and electrolytes
52
Typical stool frequency in children
Varies greatly but 3x day in \<6 months then 1x day in those 3yrs+
53
NICE guideline for constipation management in children
**If faecal impaction present:** polyethylene glycol + movicol paediatric plan - add stimulant laxative if not cleared after 2 weeks This can initially worsen symptoms and soiling Maintenance therapy: movicol paediatric plan, add stimulant laxative if no response, continue for several weeks after regular habit established then gradually reduce dose Do not use dietary advice as 1st line but do offer advice Consider behavioural interventions to encourage use of toilet Consider asking health visitor to visit to support parents
54
Management of constipation in a baby \<6 months
Bottle fed: give water between feeds, massage belly and bicycle legs Breast fed: v. unusual to be constipated so seek underlying cause
55
Management of constipation in infants who are being weaned
Offer extra water and diluted fruit juice Consider adding lactulose
56
Most common cause of diarrhoea in children?
Infection - gastroenteritis
57
Why is it important to know about a patients long-term bowel habit when taking a hx about diarrhoea?
Diarrhoea could occur following a period of constipation
58
Condition that causes an accelerated transit time and resulting dirrhoea?
Hyperthyroidism
59
Conditions that cause malabsorption in children
CF \>\> pancreatic insufficiency
60
Gastroenteritis
Very common and affects almost all children at some stage Mainly due to rotavirus - cases have dropped by 70% due to vaccine introduced in 2013 Viral causes much more common than bacterial Highly contagious Peak incidence 9-24 months Course: diarrhoea and vomiting that usually settles after 24hrs, some become severely dehydrated and may need NG oral rehydration or IV fluids if unable to keep oral rehydration solution down
61
What is toddler diarrhoea?
AKA peas and carrots condition Child is thriving and has no abnormal clinical findings but has diarrhoea with presence of undigested food Cause unknown, resolves without intervention but reduced intake of fructose in the form of fruit juice may help symptoms
62
Coeliac disease in children
1/100, occurs when weaning or after (when gluten introduced) Clinical features: bloating, poor weight gain, diarrhoea/ constipation, wasting of gluteal muscles, iron deficiency anaemia **Diagnosis:** Anti-TTG antibodies high (may be falsely low if patient deficient in IgA or they havent eaten gluten recently), biopsy shows villous atrophy, bloods show endomysial antibody **Management:** life-long gluten-free diet - risk of bowel malignancy if patients do not adhere to gluten-free diet
63
When is a child defined as being obese?
Weight \>98th centile for their age
64
When is a child defined as being overweight?
BMI between 91st-98th centile
65
Complications of obesity in children
HTN, insulin resistance, T2DM, sleep apnoea, orthopaedic problems and low self-esteem
66
Management of childhood obesity
Education education education Don't encourage a child to lose weight, encourage them to live a healthy life and gow into their weight
67
What is under-nutrition
Nutritional intake insufficient to meet the needs of the body e.g. growth and physiological function Major problem in low income countries but also seen in higher income countries where nutritional insufficiency occurs due to chronic illness Can be split into macro and micro nutrient deficiency
68
Most common micro nutrient deficiencies in the UK?
Vitamin D \>\> Rickets Iron \>\> iron deficiency anaemia
69
Discuss vitamin D deficiency
Needed for intestinal absorption of calcium and bone mineralisation Some vitamin D is taken from the diet but the most is made in the skin following UV exposure Lack of sun = lack of vitamin D = lack of calcium = lack of bone mineralisation 40% \<5yrs are vitamin D deficient Supplementation advised for pregnant/ breastfeeding women and children between 6 months - 5yrs who drink \<500ml milk daily Severe deficiency = Ricketts, seizures, cariodmyopathy
70
What is Ricketts?
Caused by lack of vitamin D Growth plates are poorly mineralised and bony deformity occurs Bowed legs, rachitic rosary (beading along ribs due to expansion of costochondral junctions), tender + swollen joints (esp. ankles and wrists) Can cause delayed walking, waddling gait, poor growth, softning of skull, symptoms of hypocalcaemia
71
Vitamin K deficiency
Usually presents with bleeding Newborn babeis have low vitamin K levels and breast milk is low in it so babies injected immediately after birth to prevent haemorrhagic disease of newborn Older children may be at risk of vitamin K deficiency if they have liver disease/ malabsorption
72
What is haemorrhagic disease of the newborn?
AKA vitamin K deficiency bleeding Preents with intracranial haemorrhage Vitamin K deficiency leads to the risk of blood coagulation problems due to impaired production of clotting factors II, VII, IX, X, protein C and protein S by the liver Uncommon in developed countries due to IM injection after birth
73
Zinc deficiency
Rare in healthy children but can occur in those with poor small intestine absorption e.g. Crohns Causes poor growth, diarrhoea and impaired immunity **_Acrodermatitis enteropathica_** = autosomal recessive condition leading to impaired absorption of zinc \>\> causes rash around mouth and perineum + alopecia + chronic diarrhoea + FTT in infancy - Responds well to zinc supplementation
74
Causes of undernutrition in children
Inadequate intake: inadequate spply, anorexia, physical feeding difficulties e.g. cerebral palsy Malabsorption Excessive nutrient loss: diarrhoea Increased metabolic demands: congenital heart disease, CF, hyperthyroidism Consequences: lack of energy, increased susceptibility to illness and infection, poor growth, poor outcomes
75
Main cause of acquired liver failure in children?
Hepatitis
76
Typical picture of hepatitis in children
Acute hepatitis: non-specific symotms e.g. fever, diarrhoea, vomiting, flu-like, jaundice 20-30% have hepatosplenomegaly, bloods show raised liver enzymes Generally self-limiting but can develop into liver failure
77
Causes of hepatitis in children
Viral (A-E), EBV and CMV Bacteria, fungal, parasitic Drugs: paracetamol Genetic: Wilson's, a anti-trypsin deficiency, haemochromatosis Autoimmune hep, lupus
78
What is Reye's syndrome?
Rare disease that causes liver damage associated with the use of aspirin in children \>\> hence aspirin not being prescribed to children unless for Kawasaki's disease
79
Cause of referred pain in abdomen of child?
Right lower lobe pneumonia
80
Congenital diaphragmatic hernia
1/2000 newborns Herniation of abdominal contents into chest cavity due t incomplete diaphragm formation Consequences: lung hypoplasia, HTN, resp. distress shortly after birth Most common = left side (85%) = Bochdalek hernia Only 50% survive dspite intervention
81
Investigation of choice for intussusception?
USS - shows a target-like mass
82
What is Dance's sign?
Empty RLQ due to intussusception seen on AXR Mass may be felt in RUQ
83
Complications of constipation
The longer the delay in treatment the longer it has to be treated for * Anal fissure * Haemorrhoids (rare in children) * Rectal prolapse * Megarectum * Faecal impaction and soiling * Volvulus * Distress and psychosocial issues
84
Management of constipation
* Children who have experienced pain when passing stools can adopt a retentive posture - straight legs on tiptoes with an arched back * Bowel habit diary - easier to manage if there is a clear picture * Rewards * Diet and lifestyle advice * Disimpaction regime: escalating dose of macrogol, if this fails add a stimulant e.g. senna. Avoid suppositories/ enemas in primary care * Secondary care: manual evacuation, polyethylene glycols via NG for whole gut lavage, antegrade colonic enema, psychological and behavioural therapies