Flashcards in Embryology Deck (14):
Reminder: define placode.
Thickened ectodermal patch on developing head
Reminder: what is the pharyngeal apparatus?
Series of external ridges and furrows with corresponding internal pouches
How do the tympanic cavity and Eustachian tube form?
1st pharyngeal pouch expands distally
How does the external auditory meatus develop?
1st pharyngeal cleft
How do the auricles form?
Proliferations within the 1st and 2nd pharyngeal arches surrounding the meatus
What is the innervation of tensor tympani and stapedius?
Tensor tympani = mandibular nerve (CNV3)
Stapedius = facial nerve (CNVII)
How does congenital inner ear deafness occur?
Maldevelopment of organ of Corti (mechanosensory hair cells in cochlea) due to teratogenic agents e.g. rubella (congenital rubella syndrome)
What are the symptoms of congenital rubella syndrome?
Eye abnormalities e.g. cataracts
Congenital heart disease e.g. patent ductus arteriosus
How does congenital middle ear deafness occur?
1st and 2nd pharyngeal arch problems
How do the eyes form?
Optic vesicles are outpocketings of forebrain
Optic vesicle grows towards surface to make contact with lens placode
Lens placode invaginates and pinches off, so it becomes surrounded by the optic vesicle (forming the optic cup: retina, iris, and ciliary body)
Optic stalk (outgrowth of forebrain) forms (will become the optic nerve)
- has choroid fissure (should close once the hyaloid artery has supplied the lens ---> degenerates distally, proximal portion becomes the central artery of the retina)
Intraretinal space is obliterated (pigment and sensory layers of retina fuse)
Ectoderm covering becomes the cornea
Extraocular muscles form from preotic myotomes
What is coloboma?
Failure of the choroid fissure to close ---> iris does not completely surround the pupil
What are the components of the optic cup?
Retina = neural (inner) and pigmented (outer) layers
RIM OF OPTIC CUP:
Iris = contractile diaphragm with central aperture
Ciliary body = muscular and vascular structure connecting choroid to lens
What is a detached retina? What is the presentation?
Separation of neural and pigment layers of the retina
e.g. retinal tear ---> space between layers filled with blood
- photopsia (flashing lights) induced by eye movements
- "curtain over vision"