EMND

Question 1

Which motor neurons does EMND primarily affect?

Answer 1

Motor neurons in the spinal cord ventral horn cells and brain stem

Question 2

Histology of EMND?

Answer 2

Non-inflammatory neuronal degeneration and loss at all levels of the spinal cord - ventral horn cells in grey matter
Degenerative axon changes in the ventral roots and peripheral nerves
All brain stem somatic motor nuclei except III, IV and VI
Atrophy of predominantly type I fibres - neurons have higher oxidative activity