Endo Flashcards
(25 cards)
Thiamine deficiency
Vit B1 def - Beri-Beri
Wernicke/Korsakoff’s
Polyneuropathy
HF
Niacin deficiency
Vit b3 def - Pellagra
Dermatitis
Diarrhoea
Dementia (confusion)
Pyridoxine deficiency
B6 def
Anaemia
Irritability
Seizures
Biotin deficiency
B7 def
Dermatitis
Seborrhoea
Folic acid deficiency
Vit B9
Megaloblastic anaemia
NTD in preg
Tocopherol deficiency
Vit E
Ataxia
Peripheral neuropathy
Mild haemolytic anaemia in newborns
Naphthoquinone deficiency
Vit K
Haemorrhagic disease of newborn
Bleeding
Cerebral salt wasting fluid status
hypovolemic hypoNa
How long to stop statin before preg
3mths
FH genetics
AD
1 in 500
Mutations in LDL receptor gene
FH dx
Simon-Broome criteria
Total cholesterol >7.5 + LDL>4.9 +
Definite if - tendon xanthomata, 1st/2nd deg relative, DNA evidence
Possible if - MI <60yrs in 1st degree, <50yrs in 2nd degree, familial raised cholesterol
SCLC endo association
SIADH
Squamous cell lung carcinoma endo association
PTHrp
When to continue GLP-1
Reduction of HBA1c of 11
Weight loss of 3% in 1st 6mths
DPP-4 inhibitors mechanism
Inhibit incretin (e.g. GLP-1) breakdown
GLP-1 action
Inhibits glucagon secretion and increases insulin
Drugs interfering with levothyroxine absorption
Calcium/Iron supplements, 4hrs apart from levothyroxine
What is Kallman’s
Hypogonadotropic hypogonadism
X-linked recessive
Kallman’s features
Anosmia + delayed puberty
Hypogonadism
Kallman’s mx
Testosterone
Gonadotropins may help fertility
Prolactinomas mx
1st line dopamine agonists - bromocriptine/cabergoline
2nd line trans-sphenoidal surgery
Graves mx
Propranolol for initial sx
Carbimazole 1st line - either titrate or block and replace
Radioiodine therapy 2nd line
Most-common cause of hypothyroid
Hashimoto’s
Hashimoto’s associations
T1DM
Coeliac
Vitiligo
MALT lymphoma
