Oncology

Question 1

Cyclophosphamide SEs

Answer 1

Haemorragic cystitis
Myelosuppression
TCC

Question 2

Bleomycin SE

Answer 2

Lung fibrosis

Question 3

Anthracyclines e.g. doxorubicin SE

Answer 3

DCM

Question 4

Methotrexate SEs

Answer 4

Mucositis
Myelosuppression
Lung fibrosis
Liver fibrosis

Question 5

5-FU SEs

Answer 5

Myelosuppression
Mucositis
Dermatitis

Question 6

6-mercaptopurine SE

Answer 6

Myelosuppression

Question 7

Cytarabine SEs

Answer 7

Myelosuppression
Ataxia

Question 8

Vincristine SEs

Answer 8

Peripheral neuropathy (reversible)
Paralytic ileus

Question 9

Vinblastine SE

Answer 9

Myelosuppression

Question 10

Docetaxel SE

Answer 10

Neutropaenia

Question 11

Irinotecan SE

Answer 11

Myelosuppression

Question 12

Cisplatin SE

Answer 12

Ototoxicity
Nephrotoxicity
Peripheral neuropathy
HypoMg

Question 13

Hydroxyurea (hydroxycarbamide) SE

Answer 13

Myelosuppression

Question 14

Li-Fraumeni syndrome features

Answer 14

AD
p53 mutations (tumour suppressor)
High incidence of mainly leukaemia + sarcomas
<45yrs with sarcoma, or <45yrs with Ca, 1st degree relative with sarcoma or Ca <45yrs

Question 15

BRCA 1 + 2 features

Answer 15

BRCA 1 chromosome 17, BRCA 2 13
Breast Ca
Ovarian Ca
Prostate in men
Pancreatic Ca
Gastric Ca

Question 16

S-100 tumour marker

Answer 16

Schwannoma
Melanoma

Question 17

Bombesin tumour-marker

Answer 17

SCLC
Gastric
Neuroblastoma