endocrine 3 Flashcards
(21 cards)
3 main families of hormones
amine derived
peptide derived
lipid/phospholipid hormones
amine derived from
tyrosine
histadine
tryptophan eg throxine
peptide hormones
water soluble
small peptide hormones (TRH)
protein hormones (insulin)
glycoprotein (LH)
lipid and phospholipid
water insoluble
prostoglandins
steroid hormones, cholesterol, testosterone
Kd = (hormone receptor interactions)
Kd= [H][L]/[HL]
limiting step is
hormone binding
secondary messengers
cAMP
cGMP
Ca2+ and calmodulin
conc of hormones is determined by 3 factors
rate of release
rate of delivery
rate of degradation and elimination
hydrophilic hormones
5 answers
cell surface transmembrane receptors channel linked receptors enzyme receptors (secondary messenger) tyrosine kinase (secondary messenger) G protein linked receptors (secondary messenger)
hydrophobic hormones
cytoplasmic receptors
problems with hormonal feedback loop
3 answers
active tumors of glands
loss of glands- autoimmune disease
loss response to hormone
hypothalamic hormones to pituitary are what type of hormones
trophic hormones
hormones run down the ———————- axon to the postierior piutuitary
paraventricular
supaventricular
all the anterior pituitary glands hormones are ______ except __________
peptides
dopamine because its alanine
all anterior pituitary glands hormones bind to _______ except ______
G coupling
dopamine
ADH, Vagus— what does it reduce and trigger
reduces plasma volume
triggers baroreceptorsin aortic arch and carotid sinus which sends signals via nerves to CNS
ADH causes
5 answers
collecting duct to insert aquaporin 2 stimulates NaCl uptake in assending loop of henle increase vasoconstriction increase water retention increase blood pressure
oxytocin causes
contraction of myoepithelial cells in mammary gland for milk release
contraction of uterus during birth
GH causes increased
protein production
cell division
cell size
after growth plates close, proportionate growth stops
Gh induces what
6 answers
expression of somatomedins increase cartilage and bone growth increase lipid metabolism decrease carbohydrate metabolism increase AA uptake increase RNA transcription/translation
what regulated blood Ca2+ levels
parathyroid hormone