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Flashcards in endocrine Deck (8)
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1
Q

what are the causes of goitres

A
graves
multinodular goitre
physiological
iodine deficiency
lithium 
infective
cancer
2
Q

what investigations should you do for goitres

A
thyroid function tests
imaging
USS, CT
needle aspiration 
biopsy
3
Q

what is cushings disease

A

ACTH producing pituitary tumour

4
Q

what is the most common cause of ectopic ACTH secretion

A

small cell lung cancer

5
Q

what are the most common causes of ACTH independent cushings syndrome

A

iatrogenic
adrenal tumour
adrenal hyperplasia

6
Q

what are the features of cushings syndrome

A
fat redistrubution
skin bruising
striae
mood changes
proximal myopathy
hypertension
impaired glucose tolerance
diabetes
pigmentation 
hypokalaemia
7
Q

what investigations can you do for cushings

A

overnight dexamethasone suppression test

24 hour urinary cortisol

midnight cortisol

plasma ACTH

CT adrenals/ thorax

high dose dexamethasone suppression test

MRI pituitary

8
Q

what medications can be used

A

metyrapone

ketoconazole