Endocrine and Development

Question 1

Describe the major function of the endocrine system.

Answer 1

The endocrine system controls cellular, tissue, and organ processes through the release of chemical signals.

These processes mainly relate to growth, metabolism, homeostasis, and reproduction.

Question 2

What is the function of an endocrine gland?

Answer 2

Endocrine glands release chemical messengers called hormones into the bloodstream. These hormones can then affect the functioning of certain organs (termed target organs).

In general, a gland is an organ or other structure that secretes products within or outside the body.

Question 3

Define:

hormone

Answer 3

A hormone is a molecule that is released into the bloodstream by an endocrine gland. Hormones act as chemical messengers and bind to receptors on their target organs.

Two large classes of hormones are peptides and steroids.

Question 4

What is the difference between negative and positive feedback?

Answer 4

In negative feedback, formation of the product of a certain process decreases the rate of that process. In positive feedback, product formation increases the rate of the process that produces it.

Negative feedback is occasionally referred to as “feedback inhibition.”

Question 5

Homeostasis is primarily maintained through which type of feedback mechanism?

Answer 5

Negative feedback maintains homeostasis.

Homeostasis relates to an organism’s need to maintain fairly stable conditions within its body and cells. Since negative feedback acts to prevent product concentrations from becoming too high, it helps preserve this stability.

Question 6

When plasma calcium levels are high, the release of parathyroid hormone is inhibited. What type of feedback does this action exemplify?

Answer 6

The inhibition of PTH by calcium is an example of negative feedback.

Parathyroid hormone (PTH) functions to increase plasma levels of calcium ion. When plenty of calcium is already present, PTH activity decreases; this prevents Ca²⁺ levels from becoming too high. Remember, negative feedback occurs when high levels of a biological product act to decrease production of that product.

Question 7

In the circulatory system, the presence of several clotting factors indirectly stimulates their own production. What type of feedback does this action exemplify?

Answer 7

Blood clotting is an example of positive feedback.

One example is thrombin, an enzyme. Thrombin activates platelets and other factors, which leads to additional thrombin production. This allows the clotting process to occur quickly.

Question 8

What type of feedback loop is seen during labor contractions?

Answer 8

Positive feedback is involved in labor.

When a pregnant female begins labor contractions, the process must be continued until birth. Oxytocin acts to stimulate these contractions, which feed back to stimulate more oxytocin release.

Question 9

What features characterize a peptide hormone?

Answer 9

Peptide hormones are polar molecules composed of amino acids.

Question 10

What features characterize a steroid hormone?

Answer 10

Steroid hormones are nonpolar molecules derived from cholesterol.

Most steroid hormones are named using the suffixes “-ol,” -one,” or “-en.”

Question 11

How do peptide hormones interact with their target cells?

Answer 11

Peptides bind to specific receptors on the cell membrane, promoting an intracellular signaling cascade.

As hydrophilic molecules, peptides cannot cross the phopholipid bilayer and never actually enter the target cell.

Question 12

How do steroid hormones interact with their target cells?

Answer 12

Steroids diffuse through the cell membrane, travel to the nucleus, and alter transcription of certain DNA sequences.

As hydrophobic molecules, steroids can easily pass through the phospholipid bilayer. However, they must be bound to a specific receptor when in the cytoplasm.

Question 13

How do steroid and peptide hormones differ in their location of synthesis within the cell?

Answer 13

Peptides are synthesized in the rough ER, while steroids are modified from cholesterol in the smooth ER.

ER stands for “endoplasmic reticulum,” a membrane-bound organelle.

Question 14

How do steroid and peptide hormones differ in their method of travel within the blood?

Answer 14

Peptides can travel freely in the bloodstream, while steroids generally must be bound to carrier proteins.

Like most differences between the hormone types, this can be explained by solubility characteristics. Peptides are hydrophilic (water-soluble), while steroids are hydrophobic.

Question 15

Name the four-ringed biological molecule that acts as the precursor for all steroid hormones.

Answer 15

Cholesterol

This molecule’s rings and hydrocarbon tail make it hydrophobic, or insoluble in water.

Question 16

Ghrelin is a hormone that acts on brain cells to stimulate hunger. It is hydrophilic (water-soluble) and interacts with target cells by binding to membrane receptors. Which type of hormone does ghrelin exemplify?

Answer 16

Ghrelin is an example of a peptide hormone.

Unlike steroids, peptides are hydrophilic, or water-soluble. They also bind to membrane receptors instead of diffusing into the cell.

Question 17

Which type of hormone requires membrane receptors to act on a target cell?

Answer 17

Peptide hormones, as well as the catecholamines epinephrine and norepinephrine, require membrane receptors.

As polar molecules, these hormones cannot pass through the hydrophobic cell membrane.

Question 18

Which endocrine gland, located adjacent to the hypothalamus, is known as the “master gland” of the endocrine system?

Answer 18

The pituitary gland is termed the “master gland” because it secretes several hormones that act on organs throughout the entire body.

The pituitary gland has two parts: the anterior (front) pituitary and the posterior (rear) pituitary.

Question 19

Which hormones are secreted by the anterior pituitary?

Answer 19

The main hormones secreted by the anterior pituitary are follicle-stimulating hormone (FSH), luteinizing hormone (LH), adrenocorticotropic hormone (ACTH), growth hormone (GH), prolactin, and thyroid-stimulating hormone (TSH).

Question 20

Which hormones are secreted by the posterior pituitary?

Answer 20

The posterior pituitary secretes antidiuretic hormone (ADH) and oxytocin.

Note that these hormones are synthesized in the hypothalamus. Only after synthesis are they transported to the pituitary for release into the blood.

Question 21

Both the anterior and posterior pituitary secrete important hormones. How do these hormones differ in their location of synthesis?

Answer 21

Hormones that are secreted from the anterior pituitary are also synthesized there. In contrast, posterior pituitary hormones are synthesized in the hypothalamus.

Question 22

What is the endocrine function of the hypothalamus?

Answer 22

The hypothalamus secretes chemicals that control the release of hormones from the anterior pituitary. It also produces the two posterior pituitary hormones, ADH and oxytocin.

The hypothalamus is connected to the pituitary via the hypophyseal portal system.

Question 23

What is a portal system, and how does it relate to endocrine function?

Answer 23

A portal system is a circulatory structure in which one capillary bed drains into another. The hypothalamus and pituitary gland are connected by such a system, which allows hormones to be easily transported from the hypothalamus to the pituitary.

Remember, the hormones of the posterior pituitary are made in the hypothalamus and simply “shipped” to the posterior pituitary for later release.

Question 24

Which endocrine gland secretes ACTH, and on what target organ does this hormone act?

Answer 24

Adrenocorticotropic hormone (ACTH) is secreted by the anterior pituitary and acts on the adrenal cortex.

Specifically, it stimulates the cortex to secrete its own hormones, which include glucocorticoids and mineralcorticoids.

Question 25

Which endocrine gland secretes prolactin, and what role does this hormone play in the human body?

Answer 25

Prolactin is secreted by the **anterior pituitary**. It stimulates the production of milk in females who are nursing infants.

Question 26

Briefly describe the role of follicle-stimulating hormone (FSH) in females.

Answer 26

In keeping with its name, FSH promotes the development of mature follicles (structures that contain egg cells). Its levels are highest before ovulation and low during pregnancy. ## Footnote Both FSH and LH are peptide hormones secreted from the anterior pituitary.

Question 27

Briefly describe the role of follicle-stimulating hormone (FSH) in males.

Answer 27

FSH facilitates spermatogenesis, or sperm production, by stimulating Sertoli cells in the testes. ## Footnote Both FSH and LH are peptide hormones secreted from the anterior pituitary.

Question 28

Briefly describe the role of luteinizing hormone (LH) in females.

Answer 28

LH promotes ovulation with a peak in concentration known as the LH surge. It also facilitates the development of the corpus luteum. ## Footnote Both FSH and LH are peptide hormones secreted from the anterior pituitary.

Question 29

Briefly describe the role of luteinizing hormone (LH) in males.

Answer 29

LH increases the production of testosterone by stimulating Leydig cells in the testes. ## Footnote Both FSH and LH are peptide hormones secreted from the anterior pituitary.

Question 30

The anterior pituitary secretes several hormones that stimulate other endocrine organs instead of non-endocrine target cells. What term describes such hormones?

Answer 30

**Tropic hormones** ## Footnote One example is TSH, or thyroid-stimulating hormone. Instead of directly altering a cellular process on its own, it stimulates the thyroid to produce its own hormones.

Question 31

What function is served by **antidiuretic hormone (ADH)**?

Answer 31

ADH stimulates the kidneys to increase water reabsorption, especially in dehydrated individuals. ## Footnote This function limits water loss, preventing blood pressure from becoming too low.

Question 32

Which endocrine gland secretes oxytocin, and what role does this hormone play in the human body?

Answer 32

Oxytocin is secreted by the **posterior pituitary**. Its main role is to facilitate labor contractions during childbirth. ## Footnote Oxytocin is also involved in other childbirth-related functions, including facilitating nursing and promoting mother-infant bonding.

Question 33

What endocrine function does the **pancreas** serve?

Answer 33

The pancreas produces and secretes insulin and glucagon, two hormones that have opposite effects on plasma glucose levels. These hormones are produced in structures termed islets of Langerhans. ## Footnote A third hormone released by the pancreas is somatostatin, but the AP Biology exam is unlikely to mention it.

Question 34

What function is served by **insulin**?

Answer 34

Insulin removes glucose from the blood and facilitates its storage in the tissues as glycogen. It is released when plasma glucose levels are high, such as after a meal. ## Footnote Insulin is secreted by pancreatic beta cells.

Question 35

What function is served by **glucagon**?

Answer 35

Glucagon facilitates the conversion of stored glycogen to glucose. This process increases plasma glucose levels. ## Footnote Glucagon is secreted by pancreatic alpha cells.

Question 36

What endocrine function does the **thyroid gland** serve?

Answer 36

The thyroid gland releases thyroid hormones, known as T₃ and T₄ (thyroxine), which control metabolism. It also secretes calcitonin. ## Footnote The endocrine activity of the thyroid is determined by thyroid-stimulating hormone (TSH), which is secreted from the anterior pituitary.

Question 37

Which hormone is produced by the parathyroid glands, and what role does it serve?

Answer 37

The parathyroid glands produce parathyroid hormone (PTH). This hormone increases plasma calcium levels by stimulating the breakdown of bone. ## Footnote Make sure to be familiar with the difference between PTH and calcitonin, which have opposite functions.

Question 38

What effect would excess production of **parathyroid hormone** have on plasma calcium levels?

Answer 38

Plasma calcium levels would increase. ## Footnote PTH is released from the parathyroid glands when plasma calcium is low. Among other functions, it stimulates the breakdown of bone, which releases calcium into the extracellular fluid.

Question 39

What effect would excess production of **calcitonin** have on plasma calcium levels?

Answer 39

Plasma calcium levels would decrease. ## Footnote Calcitonin is released from the thyroid when plasma calcium levels are high. It stimulates specialized cells to increase bone formation, taking calcium out of the blood in the process.

Question 40

Regulation of which ion involves both the thyroid and parathyroid glands?

Answer 40

Plasma concentrations of **calcium ion (Ca²⁺)** are controlled by both of these glands. ## Footnote The parathyroid glands secrete parathyroid hormone (PTH), which increases plasma calcium levels. Calcitonin, a product of the thyroid, has the opposite effect.

Question 41

Name the two major parts of the **adrenal gland**.

Answer 41

The two main parts are the **cortex**, or outer region, and the **medulla**, or inner region.

Question 42

What are the main hormones secreted by the **adrenal cortex**?

Answer 42

The adrenal cortex secretes aldosterone and cortisol. ## Footnote More broadly, the cortex produces glucocorticoids (such as cortisol and cortisone) and mineralocorticoids (such as aldosterone). It also synthesizes some sex hormones.

Question 43

What are the main hormones secreted by the **adrenal medulla**?

Answer 43

The adrenal medulla secretes epinephrine and norepinephrine, both catecholamines. ## Footnote Notably, these products can function as either hormones or neurotransmitters, depending on the location of release.

Question 44

Which type of hormone does the adrenal cortex produce?

Answer 44

The products of the adrenal cortex are **steroid hormones**. ## Footnote For the AP Biology exam, this can be remembered by recalling their broad classification: corticosteroids.

Question 45

What function is served by **aldosterone**?

Answer 45

Aldosterone stimulates the kidneys to increase sodium reabsorption; water follows and is passively reabsorbed as well. ## Footnote This function results in water retention, preventing blood pressure from becoming too low.

Question 46

Which two steroid hormones are released by the **ovaries** in females?

Answer 46

**Estrogen** and **progesterone** ## Footnote These hormones play major roles in the development of secondary sex characteristics, regulation of the menstrual cycle, and pregnancy.

Question 47

Which hormone is produced by the pineal gland, and what role does it serve?

Answer 47

The pineal gland produces melatonin, which helps regulate circadian rhythms.

Question 48

Since peptides cannot cross the cell membrane, they rely on signaling molecules inside the target cell to effect a change. What term describes this kind of pathway?

Answer 48

This pathway is a **second messenger system**. ## Footnote The first messenger is the hormone itself; the second is an intracellular ion or molecule, like Ca²⁺ or cAMP. These systems commonly involve G protein-coupled receptors, or GPCRs.

Question 49

A certain individual gets the majority of her sodium intake from uniodized sea salt. Which endocrine gland might this affect?

Answer 49

A lowered consumption of iodine might affect the **thyroid gland**. ## Footnote Iodine is required for thyroid hormone synthesis. Most table salt is iodized to protect against goiter, a condition in which the thyroid gland becomes enlarged to compensate for an iodine deficiency.

Question 50

A student reads that a certain hormone functions to increase bone resorption. Which hormone is likely being described?

Answer 50

**Parathyroid hormone (PTH)** ## Footnote It is important to know alternative ways that the AP Biology exam can phrase common terms. "Bone resorption" simply describes the breakdown of bone, which is promoted by PTH.

Question 51

A 14-year-old boy suffers from Type I diabetes. Administration of which pancreatic hormone would exacerbate (worsen) his condition?

Answer 51

**Glucagon** would make this boy's condition worse. ## Footnote Type I diabetes involves a lack of insulin, a hormone that reduces plasma glucose levels. Thus, this boy would likely have high blood sugar. Glucagon, the hormone with the opposite function of insulin, would raise his blood glucose levels further.

Question 52

What is the function of the **reproductive system**?

Answer 52

The reproductive system generates new offspring from parent organisms, facilitating the survival of the species. ## Footnote Some reproductive methods also increase genetic variation. This allows a species to adapt to changes in its environment.

Question 53

What is the difference between sexual and asexual reproduction?

Answer 53

**Sexual reproduction** involves two organisms and results in offspring that genetically differs from both of them. **Asexual reproduction** is carried out by a single organism and produces genetically identical offspring. ## Footnote All prokaryotes use asexual reproduction, though they have alternative methods of gene transfer. Eukaryotic species can reproduce sexually, asexually, or through both mechanisms.

Question 54

# Define: **gamete**

Answer 54

A **gamete** is a haploid cell that combines with another gamete during sexual reproduction. Together, the fused cells form a zygote that develops into a new organism. ## Footnote In humans, the male gamete is the sperm, while the female gamete is the egg or ovum.

Question 55

# Define: **gonads**

Answer 55

The **gonads** are endocrine organs that produce gametes. ## Footnote The female gonads are the ovaries; the male gonads are the testes.

Question 56

Name the major male and female sex hormones.

Answer 56

The most important sex hormones are **testosterone** in males and **estrogen** and **progesterone** in females. ## Footnote While these hormones are steroids, their production is closely related to that of the peptides FSH and LH.

Question 57

What is an **androgen**?

Answer 57

An **androgen** is a general term for a hormone that influences male development. ## Footnote The most important androgen to know is testosterone, a steroid hormone.

Question 58

What is **oogenesis**, and where and when does it begin?

Answer 58

**Oogenesis** is the production of the female gametes, ova, in the ovaries. ## Footnote Oogenesis begins before birth. Specifically, all of a female's oocytes are produced and arrested at prophase I by the time she is born.

Question 59

Order the following terms from least to most mature: primary oocyte, ovum, oogonium, secondary oocyte.

Answer 59

The least mature cell is the **oogonium**, which is the original parent cell in oogenesis. It is followed by the **primary oocyte**, **secondary oocyte**, and **ovum**. ## Footnote Both meiosis and mitosis are involved in this diffferentiation process.

Question 60

From birth until puberty, all of a female’s oocytes are arrested at which stage of oogenesis?

Answer 60

All of a female's oocytes are **primary** and are arrested in **prophase I** of meiosis.

Question 61

**Meiosis I** corresponds to which step of oogenesis?

Answer 61

In oogenesis, meiosis I involves the division of a primary into a secondary oocyte. ## Footnote Meiosis II, which is only completed if the egg is fertilized, involves the division of this secondary oocyte into a mature ovum.

Question 62

How many cells are produced in the differentiation of one primary oocyte into one mature ovum?

Answer 62

Oogenesis produces **three** cells per primary oocyte: one ovum and two polar bodies. ## Footnote In meiosis I, the primary oocyte divides into one secondary oocyte and one polar body. This first polar body generally does not divide further. If fertilized, the secondary oocyte undergoes meiosis II, where it divides into one ovum and a second polar body.

Question 63

Label the parts of the sperm cell below.

Answer 63

Question 64

What is **spermatogenesis**, and when and where does it begin?

Answer 64

**Spermatogenesis** is the production of the male gametes, sperm, in the seminiferous tubules of the testes. ## Footnote Spermatogenesis begins at puberty.

Question 65

Order the following terms from least to most mature: spermatid, spermatogonium, spermatozoon, secondary spermatocyte, primary spermatocyte.

Answer 65

The least mature cell is the **spermatogonium**, which is the original parent cell in spermatogenesis. It is followed by the **primary spermatocyte**, **secondary spermatocyte**, and **spermatid**. A fully mature sperm cell is known as a **spermatozoon**. ## Footnote Both meiosis and mitosis are involved in this differentiation process.

Question 66

Around what age in men does sperm production cease?

Answer 66

Spermatogenesis **never** ceases; it continues throughout a man's adult life. ## Footnote In contrast, oogenesis does not occur as a steady process. Virtually all of a woman's eggs are partially differentiated by birth, and all differentiation ceases completely at menopause.

Question 67

Name two differences between spermatogenesis and oogenesis.

Answer 67

* Spermatogenesis produces four equally functional gametes, while oogenesis produces one mature ovum and two nonfunctional polar bodies. * Spermatogenesis takes place continuously from puberty to death, while oogenesis begins before birth and ends at menopause.

Question 68

During which step of spermatogenesis do cells become haploid?

Answer 68

Developing cells become haploid during **meiosis I**, which is the division from primary to secondary spermatocyte. After this transition, the gamete will be haploid but with replicated chromosomes. ## Footnote Meiosis II, on the other hand, refers to the division from secondary spermatocyte to spermatid. After this step, the gamete will be haploid with only one copy of each chromosome, as in its final state.

Question 69

# Define: **puberty**

Answer 69

**Puberty** is the period of the human lifespan during which the reproductive system becomes mature. ## Footnote In females, this process is marked by **menarche**, or the first menstrual period. In males, spermatogenesis begins at puberty.

Question 70

Give two structural differences between the **male** and **female** reproductive systems.

Answer 70

* Male reproductive organs are mainly found outside of the body, while female organs are located internally. * In males, the urethra serves both reproductive and urinary purposes, while in females, it is only involved in urination.

Question 71

On the diagram below, label the ovaries, Fallopian tubes, uterus, and vagina.

Answer 71

Question 72

In which structure of the female reproductive system does the fertilized zygote implant?

Answer 72

The zygote implants in the endometrium (lining) of the **uterus**. ## Footnote Immediately after ovulation, this lining begins to thicken to provide a favorable environment for the potential zygote.

Question 73

What is another term used for the **Fallopian tubes**?

Answer 73

The **oviducts** ## Footnote Each Fallopian tube connects a single ovary to the uterus.

Question 74

On the diagram below, label the testes, epididymis, vas deferens, prostate gland, and urethra.

Answer 74

Question 75

What is the function of the **scrotum**?

Answer 75

The **scrotum**, which holds the testes, sits outside the body. This keeps the testes at a temperature slightly lower than 37º C, facilitating spermatogenesis.

Question 76

What process occurs in the **epididymis**?

Answer 76

In the epididymis, sperm become fully mature and motile. This structure also stores sperm after they are made.

Question 77

Name two male reproductive glands and describe their functions.

Answer 77

The **prostate gland** secretes a basic solution that protects the sperm from acidic conditions. The **bulbourethral** or **Cowper's glands** produce a lubricating fluid prior to ejaculation.

Question 78

# Define: **polar body**

Answer 78

A **polar body** is a haploid cell produced by meiosis I or meiosis II of oogenesis. Though they possess normal amounts of genetic material, polar bodies contain little cytosol and few organelles. ## Footnote Oogenesis is thus characterized by **uneven division of cytoplasm**. Most of the cytoplasm is allocated to the functioning oocyte, while little is given to the polar body.

Question 79

What is the length of an average menstrual cycle?

Answer 79

**28 days**

Question 80

Name the two simultaneous cyclical processes involved in the menstrual cycle.

Answer 80

The menstrual cycle involves the **ovarian cycle** and the **uterine cycle**. ## Footnote In general, the ovarian cycle relates to the development of the follicle within the ovary. The uterine cycle describes the buildup and degradation of the endometrial lining.

Question 81

What are the phases of the ovarian cycle?

Answer 81

The ovarian cycle contains three phases or events: the **follicular phase**, **ovulation**, and the **luteal phase**. ## Footnote The follicular phase roughly corresponds to the first half of the menstrual cycle, with the luteal phase comprising the other half. Ovulation occurs between these two phases.

Question 82

What physiological changes occur during the **follicular phase**?

Answer 82

Both LH and FSH are released at fairly high levels, stimulating the development of the follicle. The follicle itself starts to secrete estrogen. ## Footnote Remember, both LH (luteinizing hormone) and FSH (follicle-stimulating hormone) are peptides released from the anterior pituitary.

Question 83

What are **follicles**, and in which female reproductive structure are they located?

Answer 83

**Follicles** are multicellular structures located within the ovaries. Each follicle surrounds and nourishes a single oocyte. ## Footnote During ovulation, the follicle bursts and develops into the corpus luteum.

Question 84

Once every 28 days, one follicle ruptures inside the ovary, releasing an oocyte into the Fallopian tube. What term is used to refer to this process?

Answer 84

The release of an oocyte from the ovary is called **ovulation**.

Question 85

Describe the conditions that trigger ovulation.

Answer 85

Estrogen levels increase due to its release from the follicle. At this time only, estrogen exerts a positive feedback effect on LH secretion, causing a spike known as the **LH surge**. The follicle then ruptures, releasing the oocyte.

Question 86

The active ingredients of many birth control medications include synthetic estrogen and progesterone. What effect would such medications have on ovulation?

Answer 86

Ovulation would be **inhibited**. ## Footnote The presence of both estrogen and progesterone mimics the condition of pregnancy, in which FSH and LH are inhibited. Without these hormones, no LH surge can be initiated and ovulation cannot occur. In pregnancy, this effect is important to prevent multiple pregnancies from simultaneously occurring.

Question 87

What physiological changes occur during the **luteal phase**?

Answer 87

The follicle, now called the corpus luteum, begins to secrete progesterone. LH and FSH fall to very low levels. ## Footnote If fertilization occurs, implantation of the zygote would occur during this phase. Menstrual cycles, then, would temporarily cease due to pregnancy.

Question 88

# Define: **corpus luteum**

Answer 88

The **corpus luteum** is the structure that arises from the burst follicle after ovulation. If the ovum is not fertilized, it is degraded; otherwise, it persists during early pregnancy. ## Footnote Since the corpus luteum secretes progesterone, it technically functions as an endocrine gland.

Question 89

What are the three phases of the uterine cycle, and what major events do they contain?

Answer 89

1. The first phase, **menstruation**, is marked by the degeneration of the endometrial lining. 2. The second or **proliferative phase** involves regrowth of the endometrium, promoted by estrogen. 3. The final or **secretory phase** is affected by progesterone from the corpus luteum. This causes the uterine lining to release nutrients.

Question 90

How do the phases of the uterine cycle match up with the ovarian cycle?

Answer 90

The follicular phase encompasses both menstruation and the proliferative phase, while the luteal phase aligns perfectly with the secretory phase.

Question 91

Prior to ovulation, what type(s) of feedback is/are exhibited by **estrogen**?

Answer 91

Estrogen exhibits **positive** feedback, triggering the LH surge. At other times, however, estrogen negatively feeds back on LH and FSH production. ## Footnote Estrogen's activity prior to ovulation is one of the few examples of positive feedback that you may see on the AP Biology exam.

Question 92

In females, which process involves a decrease in sex hormones and the halting of ovulation?

Answer 92

**Menopause** ## Footnote Specifically, menopause is the period when menstrual cycles stop occurring and a female can no longer become pregnant.

Question 93

How many sperm cells typically fertilize a single ovum?

Answer 93

**One** sperm fertilizes each ovum, assuming fertilization occurs at all. ## Footnote Ova use specific mechanisms to avoid polyspermy, or fertilization by multiple sperm. The details of these processes are unlikely to be tested on the AP Biology exam.

Question 94

Which gamete contributes mitochondria to the developing zygote?

Answer 94

A zygote's mitochondria are contributed by the **ovum**. ## Footnote While sperm contain mitochondria, they are destroyed by the ovum shortly after fertilization. As a result, mitochondrial diseases are inherited maternally.

Question 95

# Define: **zygote**

Answer 95

The **zygote** is the diploid cell created when a sperm cell fertilizes an ovum. ## Footnote Note that a zygote is single-celled; once it undergoes a single division, it will be called an **embryo**.

Question 96

By which process does an embryo increase its number of cells, but not its overall size?

Answer 96

The early divisions of the embryo are referred to as **cleavage**. In this process, the cells divide very quickly without growing between divisions. ## Footnote The regular cell cycle includes two rest or "gap" phases, G₁ and G₂. During cleavage, dividing cells skip these phases.

Question 97

Trace the path of an zygote from the point of fertilization to the point of implantation. What structures does it encounter?

Answer 97

Fertilization occurs in the **Fallopian tubes**. From there, the zygote travels directly to the uterus and implants in the **endometrium**, or uterine lining.

Question 98

# Define: **morula**

Answer 98

The **morula** is the name given to the embryo after multiple cleavage divisions. This structure is extremely dense. ## Footnote The morula later develops into the blastula.

Question 99

What is a **blastula**, and from what other structure does it arise?

Answer 99

A **blastula** is a hollow cell arrangement that develops from the morula. A blastula contains a central **blastocoel**, a dense **inner cell mass**, and a surrounding **trophoblast**.

Question 100

What is **gastrulation**, and which germ cell layers does it produce?

Answer 100

**Gastrulation** is the differentiation of the blastula into three distinct layers: the ectoderm, the mesoderm, and the endoderm.

Question 101

# Define: **endoderm**

Answer 101

The **endoderm** is the innermost germ layer formed during development. ## Footnote Structures arising from the endoderm include internal organs such as the pancreas and urinary bladder. The endoderm also gives rise to the linings of the digestive tract and lungs.

Question 102

# Define: **ectoderm**

Answer 102

The **ectoderm** is the outermost germ layer formed during development. ## Footnote Structures arising from the ectoderm include the eyes, skin, hair, nails, and nervous system.

Question 103

# Define: **mesoderm**

Answer 103

The **mesoderm** is the middle germ layer formed during development. ## Footnote Structures arising from the mesoderm include blood vessels, gonads, and the muscular and skeletal systems. Note that the kidneys also derive from mesoderm, not endoderm.

Question 104

A student asserts that the endoderm gives rise to internal organs like the pancreas, lungs, kidneys, and urinary bladder. About which structure was the student incorrect?

Answer 104

The student was wrong about the **kidneys**, which develop from the mesoderm. ## Footnote The remaining organs (pancreas, lungs, and urinary bladder) do arise from the endoderm.

Question 105

What process involves the differentiation of ectodermal tissue into the structures that will become the nervous system?

Answer 105

This differentiation process is called **neurulation**. ## Footnote The final product of neurulation is the **neural tube**, which develops into the central nervous system. Peripheral nervous structures arise from cells of the **neural crest**.

Question 106

Briefly describe the steps involved in **neurulation**.

Answer 106

1. The **notochord**, a long, cylindrical structure related to the backbone, forms. 2. The **neural plate** (ectoderm lying above the notochord) begins pinching inward to create **neural folds**. 3. The neural folds meet, forming the **neural tube**. 4. **Neural crest** cells move away to form peripheral structures.

Question 107

After what amount of time has the zygote progressed into an **embryo**? Into a **fetus**?

Answer 107

The zygote is considered an **embryo** after its first cell division. The embryo is classified as a **fetus** during the first trimester, specifically after the eighth week following fertilization.

Question 108

Which hormone, commonly detected in pregnancy tests, prevents the corpus luteum from degrading after implantation?

Answer 108

**Human chorionic gonadotropin (hCG)**, a classic sign of pregnancy, maintains the corpus luteum. ## Footnote Note that hCG is a peptide hormone.

Question 109

Which hormone, released from the anterior pituitary, promotes lactation after birth?

Answer 109

**Prolactin**, a peptide hormone, promotes lactation.

Question 110

A woman is midway through her second trimester of pregnancy. Which of her hormones will be present at high levels?

Answer 110

**Estrogen**, **progesterone**, and **hCG** exist at high levels during pregnancy. ## Footnote In early pregnancy, progesterone and some estrogen are secreted by the corpus luteum. Within the third month, the placenta becomes the main source of these hormones, as well as hCG.

Question 111

# Define: **placenta**

Answer 111

The **placenta** is the organ through which a fetus obtains nutrients and performs gas exchange. ## Footnote The placenta also performs endocrine functions, secreting estrogen, progesterone, and hCG.