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Flashcards in Endocrine Disorders And Drugs Deck (25)
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1

Panhypopituitarism (children)

decrease in all anterior pituitary hormones causing pituitary dwarfism; proportionally small and no puberty; congenital or tumor

2

Adolescence with Low GH

treated with hGH; somatotropin issue, but normal sexual development

3

Somatomedin (IGF-1) associated Dwarfism

Laron: GH receptors in liver are defective and no IGFs produced
African Pygamy: lack rise in IGF during puberty

4

Panhypopituitarism (adults)

tumors or low blood flow; no growth issues with bones, but ACTH and thyroid missing can cause lethargy

5

Gigantism

adolescence; over activity of acidophils; hyperglycemia and diabetes are common symptoms because GH increases blood glucose

6

Acromegaly

occurs in adults; acidophilic tumor after puberty; no height increase, but bones become thicker, soft tissue and cartilage growth, cardiac hypertrophy, visual impairments, diabetes, and high glucose due to GH

7

Treatments for high amount of GH

inject somatostatin, resect the tumor, GH receptor antagonist, and dopamine in ELEVATED conditions ONLY or will increase GH

8

SIADH

increase in ADH; causes hypertension, edema, hypotonic conditions, and concentrated urine

9

Diabetes Insipidus

low ADH; causes low BP and blood plasma, hypernatremia in ECF, and dilute urine

10

Hyperthyroidism

high T3 and T4, but low TSH; causes muscle breakdown and diarrhea; increases PTH activity because Ca2+ is needed

11

Grave's Disease

autoimmune disorder where TSI antibodies bind to TSH receptor to cause TSH to increase, therefore increasing T3 and T4 and the negative feedback causes a decrease in actual TSH, but the TSIs keep the thyroid hormones high. Form of hyperthyroidism

12

Thyroid Adenoma

secretes thyroid hormone (T3/T4) so TSH levels are low; cause of hyperthyroidism

13

Goiter (hyperthyroidism)

Enlarged thyroid due to an increase in T3 and T4 hormones; T3 and T4 have a trophic effect on the thyroid because they promote its growth

14

Symptoms of Hyperthyroidism

heat intolerance, weight loss, increased excitability, muscle weakness, increased cardiovascular stimulation, fatigue but inability to sleep, exophthalmos (swelling of eye orbitals causing protrusion of the eyes)

15

Diagnosis of Hyperthyroidism

radioimmunoassay measuring T3, increased BMR, TSH near zero, and immune system measurements

16

Treatment of Hyperthyroidism

resectomy of thyroid with hormone replacement therapy, although risk of thyroid storm, radioactive iodine, and antithyroid drugs
Thiocyanate, perchlorate, and nitrate inhibit transport of I
Propylthiouracil is a peroxidase inhibitor so I cannot attach to TG

17

Hasimoto's

autoimmune destruction of thyroid leading to fibrosis and decrease in T3 and T4; form of hypothyroidism

18

Congenital Hypothyroidism

cretinism; defective thyroid or pituitary; low T3 and T4 synthesis; neurological symptoms as well

19

I deficiency

endemic called goiter; high TSH stimulates TG secretion into follicles; hypothyroidism

20

Idiopathic Colloid Goiter

normal I levels, but issues with enzymes in follicle; form of hypothyroidism

21

Antithyroid Compounds

in foods; thiocyanate and propylthiouracil in broccoli, brussel sprouts, etc.

22

Hypothyroidism Symptoms

cold intolerance, weight gain, fatigue with excessive sleep, high cholesterol causing atherosclerosis, low HR and CO, myxedema (bags under the eyes and facial swelling due to increased interstitial fluid)

23

Hypothyroidism Diagnosis

radioimmunoassay of T3 in plasma, low BMR, and high TSH

24

Hypothyroidism Treatment

T4 hormone replacement therapy, which is extremely effective

25

Lack of StAR Protein

lack sex steroid hormones because unable to bring cholesterol into the mitochondria (rate limiting step)