Endocrine disrupters

Question 1

Endocrine disruptors

Answer 1

Interferes with the action of a hormone (production, secretion, transport, metabolism, receptor binding, effect, excretion).
Potentially lead to epigenetic and transgenerational effects.

Question 2

Examples

Answer 2

phthalates (glues, detergents, painst, drugs, food wraps, textiles, MEP-cosmetics)
BPA-plasticisers
parabens
dioxins
pesticides
PFAS (polyfluoroalkyl substances)
Drugs - paracetamol, aspirin, indomethicin (can interfere with testicular descent)

Question 3

Reducing exposure

Answer 3

Question 4

Animal and human epidemiological studies linked

Answer 4

Women:
Fibroids
Endometriosis
PCOS
DOR
POI
Infertility
Cancer
Boys:
Testicular cancer, cryptorchidims, reduced semen analysis

Question 5

Difficulties in researching

Answer 5

Challenges with reporting data, what is prenatal, early or contemporary exposure, so many confounders, use of add-mixture measures.
Purely associations
Can have agonist, and antagonist effects
Do not follow standard dose response curves.
Difficulties studying effects over generations