Endocrine Drugs Flashcards
(31 cards)
Posterior pituitary
Neurohypophysis
Storage vesicle
Anteriorp ituitary functions
Adenohypophysis
Secretion of releasing and inhibiting hormones
Moa endocrine
Binds to plasma membrane
To intracellular receptors- cytoplasmic and nuclear
Growth hormone moa
Stimulates liver to produce somatomedins
Produces growth at open epiphyses via IGF1
Children- linear growth of skel muscle
Adult- anabolic effect
GH indications
Hypopituitary dwarfism
Non gh deficient short child
Toxicity gh
CJD
Problems in hip, knee, spine
Pegvisomant- gh antag
Acromegaly, excessive gh
Somatomedin c
Igf-1
For growth failure due to igf1 deficiency
Somatostatin
Blocks gh, tsh, insulin, glucagon
Indications of somatostatin analogs
Acromegaly
Tsh secreting pituitary adenomas
Carcinoid tumors
VIP secreting tumors
What is trh for
Diagnostics
Thyrotropin alfa
Stimulate RAI by metastatic thyroid ca
Im, sq
Corticotropin releaing hormone
Diagnostic!
Diff cushings from ectopic acth
Cushing inc acth
Acth
Diagnostic
Tetracosactide
Therapeutic goal of gnrh agonist
Reversible hypogonadism
Indications gnrh agonist
Med menopause
Female disorders dept on estrogen(endometriosis)
Ivf therapy
Delay puberty in indiv with precocious puberty
Side effects gnrh
Hot flushes
Osteoporosis
Gnrh antag
Blocks receptors
No flare effect
Prevention of endogenous ovulation
Abarelix
Palliative treatment of adv symptomatic prostate ca
Cetrorelix and ganirelix
Inhibition of premature lh surges
Fsh
Women- follicular devt, androgen to estrogen, twins
Men- spermatogenesis, production of abp
Highly purified prep of human fsh from urine of post mens
Urofollitropin
Follitropin alfa and beta
No lh activity
Lh
Induce ovulation
Lutropin alfa- only source of pure lh
