Endocrinology Flashcards
(5 cards)
1
Q
What is the definitive treatment for primary hyperparathyroidism?
A
Total parathyroidectomy
2
Q
Which antidiabetic medication class works by binding to ATP-dependent K+ channels (K-ATP) on cell membranes of pancreatic beta cells?
A
Sulfonylureas
3
Q
Give 3 possible side effects of sulfonylurea medications.
A
Weight gain, hypoglycaemia, GI upset.
4
Q
What is the mechanism of action of sulfonylureas?
A
Bind to K-ATP channels on the pancreatic beta cell membrane to stimulate endogenous insulin secretion.
5
Q
What is the mechanism of action of thiazolidinediones (glitazones)?
A
Activation of PPAR (peroxisome proliferator-activated receptor-gamma), resulting in increased insulin sensitivity.
