Enoxaparin

Question 1

Drug class

Answer 1

Anticoagulant

Question 2

Pharmacology

Answer 2

Has several actions on the coagulation pathway through its binding to antithrombin III. The antithrombotic activity relates to the inhibition of thrombin generation & inhibition of coagulation factor Xa & thrombin

Question 3

Metabolism

Answer 3

Heaptic but mostly eliminated unchanged

Question 4

Indications

Answer 4

Pts with STEMI (as per CARC) who have received QAS tenecteplase (as an adjunct medication to aspirin & clopidogrel)

Question 5

Contraindications

Answer 5

• Allergy and/or adverse drug reaction

* Pts contraindicated for pre-hosp fibrinolysis administration

Question 6

Precautions

Answer 6

• Renal/hepatic impairment
• Low bodyweight (women < 45kg & men <57kg)
• Older people

Question 7

Side effects

Answer 7

• Haemorrhage

* Thrombocytopenia

Question 8

Presentation

Answer 8

• Injection 60mg/0.6ml pre-filled syringe

* Injection 100mg/1ml pre-filled syringe

Question 9

Onset

Duration

Answer 9

IV:
Immediate
12-24hrs

Question 10

Routes of Administration

Answer 10

SUBCUT

IV

Question 11

Adult dosages

Answer 11

Pts with STEMI (as per CARC) who have received QAS tenecteplase (as an adjunct medication to aspirin & clopidogrel)

IV - loading dose 30mg
*All IV admins must use 60mg/0.6ml (use markings & air bubble is NOT to be admin)

SUBCUT - 1mg/kg
15min after loading dose
Single dose only, not to exceed 100mg
*Use 100mg/1ml, needle down, bottom of air bubble level with correct marking, air bubble req to be admin