Enteric Viral Infections Flashcards
What is the mechanism of transmission of EV-D68?
Respiratory
What is Pleconaril useful for?
Immunocompromised people with severe disseminated disease with EV-D68
Which vaccine is effective post-exposure?
Hepatitis A
What type of vaccine is the hepatitis A vaccine?
Killed vaccine- IM injection
How is at a higher risk for severe respiratory illness caused by EV-D68?
Children with asthma- severe symptoms include wheezing and difficulty breathing
What time of the year are people more likely to get infected with enteroviruses?
Summer and fall
What is the MOA of Pleconaril?
Drug incorporates into viral particles and changes the shape of the particle such that it can no longer bind a receptor to infect a new host cell
Pleconaril is the first antiviral drug to have activity against which class of viruses?
Picornaviruses (predominant cause of the common cold)
What part of the body is affected by rotavirus?
Infection with rotavirus is primarily restricted to the villus epithelium of the small intestine
What age group has a symptomatic infection with rotavirus?
Outcome of infection is age-related: symptomatic infection occurs in young Children 6 months to 2 years of age
What is the pathogenesis of diarrhea with rotavirus?
Ca2+ released by NSP4 –> diarrhea
Describe the rotavirus vaccine.
Pentameric live-attenuated vaccine that gives a 98% protection against severe disease
Antibodies against which two rotavirus viral proteins are neutralizing?
VP4, VP7
What type of viruses undergo reassortment?
Segmented viruses- rotavirus and influenza virus
What is the transmission of rotavirus?
Fecal-oral
