Enterics (Virulence Factors and targets)

Question 1

V cholerae

Answer 1

Cholera toxin targets Adenylate cyclase

Question 2

ETEC

Answer 2

Heat labile enterotoxin targets Adenylate cyclase

Heat stable targets Guanylate cyclase

Question 3

EPEC

Answer 3

LEE T3SS targets pedestal fomation

Question 4

EHEC

Answer 4

LEE T3SS targets pedestal formation

Shiga toxin causes hemorrhagic collitis, HUS (hemolyic uremic syndrome that leads to kidney failure)

Question 5

Shigella spp

Answer 5

T3SS targets uptake, apoptosis, causes inflammation

Question 6

Shigella dysenteriae

Answer 6

T3SS, shiga toxin, targets, uptake, causes inflammation, dysentery, HUS

Question 7

Nontyphoidal Salmonella

Answer 7

SPI1 T3SS targets uptake

SPI2 T3SS - intracellular survival, causes diarrhea

Question 8

Salmonella typhi

Answer 8

SPI1 T3SS, SPI2 T3SS, capsule, typhoid toxin

Targets: uptake, intracelleular survival, eneric fever, macrophages

Question 9

Campylobacter

Answer 9

Flagella, cytolethal distending toxin targets epithelial cells