entry and spread Flashcards by Reilly Richardson

S. aureus multiplication

can grow in almost any tissue site

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S. aureus entry

entry via skin to skin contact, injury from contaminated object, inhalation, ingestiion

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S. pyogenes multiplication

extracellular growth on mucous membranes, skin, deep tissue

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S.pyogenes entry

person to person via respiratory droplets, skin to skin contact, contact w/ fomite

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S. pneumoniae multiplication

extracellular growth on mucous membranes of respiratory tract or in blood

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S. pneumoniae entry

person to person through respiratory droplets

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B. anthracis entry

point source via innoculation of spores into break in skin, inhalation, ingestion (rare)

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B. cereus multiplication

can grow in almost any tissue site

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B. cereus entry

ingestion of contaminated food

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L. pneumophila multiplication

intracellular growth in alveolar macrophages, prevents maturation of phago-lysosome

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L. pneumophila entry

inhalation of aerosols of contaminated water

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L. monocytogenes multiplication

intracellular growth in intestinal epithelial cells, M-cells, macrophages, neutrophils, replicates in cytoplasm - escapes the phagosome

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L. monocytogenes entry

ingestion of contaminated food

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M. tuberculosis multiplication

intracellularly in colonies of alveolar macrosphaes, replicating in specialized vacuole and/or possibly cytosol - resistance to phagolysosome digestion components, prevent maturation of phagolysosome

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M. tuberculosis entry

human to human spread via inhalation of contaminated respiratory secretions

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C. diphtheriae multiplication

extracellular in oropharynx

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C. diphtheriae entry

inhalation of contaminated respiratory droplets

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B. pertussis multiplication

extracellular

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B. pertussis entry

inhalation of contaminated respiratory droplets

E. coli multiplication

extracellular (ETEC, EPEC, EHEC), intracellular (UPEC)

E. coli entry

ingestion, wound infections, endogenous (EPEC person to person)

S. enterica ssp. enterica multiplication

intracellular in intestinal epithelial cell, M-cells, leukocytes

S. enterica ssp. enterica entry

ingestion of contaminated food or water

Y. pestis multiplication

extracellular in lymphatic system

Y. pestis entry

infected flea bite or aerosolized respiratory droplets

Shigella spp. multiplication

intracellular in intestinal epithelial cells

Shigella spp. entry

person to person or via ingestion of contaminated food or water

C. perfringens multiplication

extracellular anaerobic growth in soft tissue or intestinal tract

C. perfringens entry

wound infection by spores

C. tetani multiplication

extracelluar anarobic

C. tetani entry

point object

C. difficile multiplication

extracellular anaerobic growth in colon (large intestine)

C. difficile entry

ingestion or normal flora, facilitated by antibiotics

C. botulinum multiplication

spores germinate IN FOOD SOURCE - exception infant botulism - spores germinae in intestine

C. botulinum entry

ingestion of toxin contaminated food, ingestion of spores (infant only)

N. gonorrheae multiplication

extracellularly in mucosal bsolateral surfaces of urogenital tract

N. gonorrheae entry

sexual contact w/ infected individual

N. meningitidis multiplication

extracellularly in mucosal bsolateral surfaces of upper respiratory tract

N. meningitidis entry

inhalation of contaminated respiratory droplets

T. pallidum multiplication

extracellular and intracellular

T. pallidum entry

human to human spread via sexual contact or maternal transfer to child

Influenza multiplication

genome transcribed and replicated in nucleus

Influenza entry

inhalation of contaminated respiratory droplets (human to human for A, B, C, animal to human is possible for type A only

measles multiplication

infects macrophages and dendritic cells of respiratory tract, submucosa, then disseminates via lymph and blood - genome uncoats in cytoplasm

measles entry

inhalation of contaminated respiratory droplets