entry/gateway to TCA

Question 1

what enters the tca cycle first

Answer 1

pyruvate

Question 2

what vitamin does CoA have

Answer 2

pantothenate B5

Question 3

what is the role of CoA

Answer 3

carrier of acyl gps and it transfers acyl gps

Question 4

is CoA a high energy bond

Answer 4

yes bc it has a thiol group

Question 5

what are the cofactors of pdh

Answer 5

TPP, lipoic acid, coA, FAD, NAD+

Question 6

where is TPP cofactor located

Answer 6

bound to E1

Question 7

what is the function of TPP

Answer 7

decarboxylates pyruvate

Question 8

where is lipoic acid located and the function

Answer 8

covalently linked to a Lys
accepts hydroxyethy;

Question 9

what is the Location and function of coA

Answer 9

substrate for E2
accepts acetyl group from lipoamide

Question 10

what is the location and function of FAD

Answer 10

bound to E3
reduced by lipoamide

Question 11

what is the location and function of NAd+

Answer 11

substrate for E3
reduced by FADH2

Question 12

what cofactors are catalytic

Answer 12

TPP and lipoic acid

Question 13

what cofactors are stoichiometric

Answer 13

CoA, FAD, NAD

Question 14

what is used to add the acetyl group to oxoloacetate to give citrate

Answer 14

the energy of the thioester

Question 15

what is succinyl CoA

Answer 15

• nucleoside triphosphate - ATP in prok and GTP in euk

Question 16

what drives synthesis of succinyl CoA

Answer 16

hydrolysis of CoA ester

Question 17

what does the mechanism of Succin. CoA involve

Answer 17

phosphohistidine

Question 18

what competitively inhibits succinate DH

Answer 18

malonate

Question 19

what happens during rxn for succinate dh

Answer 19

hydride transfer + oxidation w/ FAD and its reduced to covalently attatch to the enzyme

Question 20

what is the only membrane bound enzyme of TCA

Answer 20

succinate dh bc its complex 2 of the etc

Question 21

where is succinate DH bound

Answer 21

to the inner mito membrane

Question 22

fumarase is reversible why?

Answer 22

it is a lyase meaning its reversible q

Question 23

mneominc for the tca

Answer 23

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Question 24

tca step 1

Answer 24

oxaloacetate to citrate w/ citrate synthase

Question 25

tca step 2

Answer 25

citrate to isocirate w/ acontinase

Question 26

tca step 3

Answer 26

isocitrate to alpha ketoglut w/ isocitrate DH

Question 27

tca step 4

Answer 27

alpha keto to succinyl co A w/ alpha keto DH

Question 28

tca 5

Answer 28

succinyl coA to succinate w/ succinyl CoA synthetase

Question 29

tca 6

Answer 29

succinate to fumarate s succinate DH

Question 30

tca 7

Answer 30

fumarate to malate fumarase

Question 31

tca 8

Answer 31

malate to oxoloacateta malate DH

Question 32

energy cost of 1 acetyl gp in the krebc

Answer 32

2 co2, 1 gtp(ATP in prok) 3 NADH 1 FADH

Question 33

what are ways to control negative feedback

Answer 33

feedback inhibition product inhibition

Question 34

what is negative feedback

Answer 34

the output of a process inhibits the process

Question 35

feedback inhibition

Answer 35

product inhibts the enzyme further upstream

Question 36

product inhibition

Answer 36

product of an enzyme cat. rxn binds to it inhibiting it

Question 37

what regulates PDH

Answer 37

product inhibition NADH competes withNAD + acetyl CoA comples with CoA for binding @e2