ENZYME INHIBITION Flashcards
(53 cards)
slows down or blocks enzyme activity.
Enzyme inhibition
are molecules that
prevent enzymes from doing
their job.
Inhibitors
This is important in both
nature and medicine.
Enzyme inhibition
3 MAIN TYPES OF INHIBIITORS
COMPETITIVE INHIBITOR
NON-COMPETITIVE INHIBITOR
IRREVERSIBLE INHIBITOR
competes with the substrate at the active sites
COMPETETIVE INHIBITOR
binds to a different part of the enzyme
NON-COMPETITIVE INHIBITOR
permanently deactivates the enzyme
IRREVERSIBLE INHIBITOR
is a molecule that slows down a reaction by taking the place of the real substance at the enzyme’s working site.
Competitive Inhibition
is a molecule that slows down a reaction by attaching to a different part of the enzyme, changing its shape so it can’t work properly.
Non-competitive Inhibitor
is a molecule that permanently blocks the enzyme by tightly binding to it, stopping it from working forever.
Irriversible Inhibition
3 Regulation of Enzyme Activity
Feedback inhibition
Allosteric regulation
Environmental factors
It is the end product of
a pathway inhibits an earlier enzyme.
Feedback inhibition
it is when molecules bind to a site other than the active site to change activity.
Allosteric regulation
can increase or decrease activity
pH and temperature
it is when pH and temperature can increase ordecrease activity
Environmental factors
The end product of a metabolic pathway stops or slows down an earlier step.
Feedback Inhibition
Prevents the cell from making more than it needs.
Feedback Inhibition
slows down its own production when enough is made.
ATP
Maintains balance inside cells (homeostasis).
Feedback Inhibition
Saves energy and resources.
Feedback Inhibition
A common natural way the body controls enzyme activity.
Feedback Inhibition
A molecule binds to a regulatory (allosteric) site, not the active site.
Allosteric Regulation
This changes the enzyme’s shape and activity (can increase or decrease it).
Allosteric Regulation
Common enzymes with multiple subunits.
Allosteric Regulation