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Clinical Chemistry > Enzymes > Flashcards

Enzymes Flashcards

1
Q

The appearance of LD-1/LD-2 flipped pattern and the presence of CK-MB isoenzyme on electrophoresis is highly suggestive of?

A

Myocardial Infarction

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2
Q

classification/sub-classification of Alanine amino transferase

A

Aminotransferase

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3
Q

classification/sub-classification of creatine phosphokinase

A

Phosphotransferase

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4
Q

classification/sub-classification alkaline phosphate

A

Esterase

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5
Q

classification/sub-classification of amylase

A

Glycosidase

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6
Q

classification/sub-classification of lactate dehydrogenase

A

Oxidoreductase

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7
Q

Disease causing increase in ACP

A

Hairy cell leukemia

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8
Q

Disease causing increased in CK-MB

A

Myocardial infarction

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9
Q

Disease causing increased in amylase

A

Pancreatitis

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10
Q

Disease causing increased in AST

A

Muscle trauma

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11
Q

Disease causing increased in lipase

A

Pancreatitis

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12
Q

In enzyme kinetics, what do we call the speed of enzyme reaction that initially increases as the substance increases?

A

First order kinetics

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13
Q

Which of the following methods for alkaline phosphatase uses buffered phenolphthalein phosphate as substrate?

A

Klein-Babson-Reed

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14
Q

One of the following is a coenzyme in the LDH catalyzed reaction

A

NAD/NADH

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15
Q

The De Ritis ratio is a very useful indicator of the etiology of liver disease. What is the indication if the De Ritis ratio is very high?

A

Alcoholic liver disease

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16
Q

The following laboratory results is suggestive of what condition?
I. Alkaline phosphatase = extremely high II. Direct bilirubin = normal
III. Gamma glutamyl transferase=normal IV. Alanine transferase= normal

A

Paget’s disease

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17
Q

One of the following is not a reason for increased enzyme activity.

A

Reaction lacks co-factors

18
Q

Tissue source of ACP

A

Rbc

19
Q

Tissue source of lipase

A

Pancreas

20
Q

Tissue source of AST

A

Skeletal muscle

21
Q

Tissue source of amylase

A

Pancreas

22
Q

Tissue source of CK-MB

A

Myocardium

23
Q

Which of the following functions as a coenzyme in transaminase reaction?

A

Pyridoxal phosphate

24
Q

The term to describe loss of activity of the enzyme because of physical processes such as heat, mechanical agitation, irradiation is called?

A

Denaturation

25
Q

In amylase determination, the method that measures the disappearance of starch substrate is:

A

Amyloclastic

26
Q

Which of the following enzymes exhibit the least tissue specificity?

A

LDH

27
Q

What ALP isoenzyme has the same properties as the Regan isoenzyme?

A

Placental

28
Q

LDH levels are increased in the following disease except:

A

Pancreatitis

29
Q

catalyzes the removal of a group of atoms from the substrate

A

Lyases

30
Q

Catalyzes group transfer reaction

A

Transferase

31
Q

Catalyzes hydrolytic reaction

A

Hydrolase

32
Q

Catalyzes the reduction reactions

A

Oxido-reductase

33
Q

Catalyzes reactions involving isomeration

A

Isomerase

34
Q

This theory allows some degree of conformational change after binding of substrate and active site so as to form a stronger association.

A

Induce fit

35
Q

From the items listed below, identify the reason for the increase in urinary amylase activity in acute pancreatitis.

A

There is an increased renal clearance of amylase

36
Q

One of the following is the term used when an enzyme activity being measured is coupled with a colorimetric reaction.

A

Coupled enzyme reaction

37
Q

The enzyme that acts on several phosphate ester substrates and exhibit low tissue specificity is:

A

ALP

38
Q

One of the following is the term used when an enzyme activity being measured is coupled with a colorimetric reaction.

A

Coupled enzyme reaction

39
Q

The enzyme that acts on several phosphate ester substrates and exhibit low tissue specificity is:

A

ALP

40
Q

Which of the following is the substrate of choice for measuring acid phosphatase activity?

A

Thymolphthalein monophosphate

41
Q

Which amylase of the following methods for amylase determination measures the amount of starch hydrolyzed within a specified time?

A

Amylometric

42
Q

The end color of starch using iodine after its completely hydrolyzed.

A

Brown

Clinical Chemistry (12 decks)

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