Lipids

Question 1

In familial hypercholesterolemia, the hallmark finding is an elevation of one of the following”

Answer 1

LDL

Question 2

If the LDL-cholesterol is to be calculated by the Friedewald formula, what two measurements must be carried out using the same chemical procedure.

Answer 2

Total cholesterol and HDL cholesterol

Question 3

A molecule common to both the citric acid cycle and lipid metabolism is____.

Answer 3

Acetyl CoA

Question 4

What will be the concentration of HDL cholesterol given the following data:
OD of unknown= 0.175
OD of standard= 0.22
Concentration of standard= 1,17 mmol/L

Answer 4

0.93

Question 5

The function of the major lipid components of the VLDL is to transport:

Answer 5

Endogenous triglycerides

Question 6

High levels of which lipoprotein class are associated with decreased risk of accelerated atherosclerosis?

Answer 6

HDL

Question 7

The lipoprotein that travels with B globulins during electrophoresis is ____.

Answer 7

LDL

Question 8

______ are proteins that combine with lipids and aid in their transport.

Answer 8

Lipoproteins

Question 9

The type of lipoprotein with a high atherogenic potential is ______.

Answer 9

LDL

Question 10

As part of the hyperlipidemia screening program, the results below were obtained from a 25 year old 6 hours after eating. Which of the choices below is the BEST interpretation of these results? Triglycerides= 2,93 mmol/L Cholesterol= 3,10 mmol/L

Answer 10

The cholesterol may be normal but
the triglycerides are elevated which
may be attributed to the recent meal

Question 11

Turbidity in serum suggests elevation of:

Answer 11

Chylomicrons

Question 12

The parent substance in the biosynthesis of androgen and estrogens is:

Answer 12

Cholesterol

Question 13

____ is used to precipitate proteins in the Bloor’s method for cholesterol determination.

Answer 13

CHCI3

Question 14

The lipoprotein that transports endogenous triglycerides is _______.

Answer 14

VLDL

Question 15

An increase in fats and fatty acids in the blood is called _____.

Answer 15

Hyperlipidemia

Question 16

The most widely used support medium for electrophoretic separation of lipoprotein is:

Answer 16

Agarose gel

Question 17

The precipitant of choice in the non enzymatic method for cholesterol determination is ______.

Answer 17

Digitonin

Question 18

Which of the following lipid results would be expected to be falsely elevated on a serum specimen from a non-fasting patient?

Answer 18

Triglycerides

Question 19

_____ seconds is the peak absorbance in Ferro-Ham method for cholesterol determination.

Answer 19

60

Question 20

The organ that plays an important role in cholesterol metabolism is ____

Answer 20

Liver

Question 21

______ is the breakdown or hydrolysis of a substance such as triglycerides into fatty acids.

Answer 21

Saponification

Question 22

A fasting serum sample from an asymptomatic 43-year old woman was examined visually and chemically with the results shown below. What lipoprotein fractions would predominate? Initial appearance of serum is milky. After an overnight refrigeration a cream layer over a turbid serum was found
Triglyceride level= 22,58 mmol/L Cholesterol level= 14,22 mmol/L

Answer 22

Chylomicrons
VLDL

Question 23

What will be the cholesterol value for the data below:
OD of unknown= 0.455
OD of standard= 0.32
Concentration of standard= 5,27 mmol/L

Answer 23

7.35

Question 24

Which of the following diseases results from a familial absence of HDL?

Answer 24

Tangier

Question 25

not considered as a polyanion precipitant:

Answer 25

Digitonon

Question 26

What transports 60-77% of the plasma cholesterol?

Answer 26

LDL

Question 27

The most metabolically active plasma lipids is ______.

Answer 27

FFA

Question 28

Most of the cholesterol esters found in the blood are cholesterol combined with

Answer 28

LDL

Question 29

The most consistent analytical error involved in the routine determination of HDL-cholesterol is caused by:

Answer 29

Co-precipitate of HDL and LDL-cholesterol

Question 30

Premature atherosclerosis can occur when which of the following becomes elevated?

Answer 30

LDL

Question 31

In the colorimetric and fluorometric triglyceride assays, glycerol is oxidized to _______.

Answer 31

Formaldehyde

Question 32

The lipoprotein that possesses Apo B 48 is _______.

Answer 32

Chylomicrons

Question 33

In lipoprotein phenotyping, chylomicrons are present in the plasma of persons with which of the following lipoprotein phenotypes?

Answer 33

I and IV

Question 34

What will be the triglyceride concentration given the data below: OD of unknown= 0.30 OD of standard= 0.265 Concentration of standard= 2,59mmol/L

Answer 34

2,93

Question 35

Most of the fatty acids are bound by ____ in the plasma.

Answer 35

Albumin

Question 36

Apolipoprotein B (Apo-B-100) is the major apolipoprotein found in:

Answer 36

LDL

Question 37

Using the value you have obtained to compute Total cholesterol, triglycerides and HDL-cholesterol, what will be the LDL cholesterol?

Answer 37

5,09 mmol/L

Question 38

Triglycerides in circulation are cleared by the enzyme

Answer 38

Lipoprotein lipase

Question 39

____ lipoprotein transport cholesterol to other tissues for membrane and steroid synthesis.

Answer 39

LDL

Question 40

Bile acids are synthesized from _____.

Answer 40

Cholesterol