Epigenetics Flashcards Preview

Genetics exam #3 > Epigenetics > Flashcards

Flashcards in Epigenetics Deck (19)
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0
Q

during epigenetics, there is ____ ________ in DNA seq

A

no change

1
Q

study of heritable traits that are also reversible

  • cell to cell (mitosis)
  • parent to offspring (meiosis)
A

epigenetics

2
Q

many epigenetic traits not passed ______ to _______

A

parent to offspring

3
Q

molecular basis of epigenetic inheritance

A
DNA methylation of cytosine
chromatin remodeling
covalent histone modifications
histone variants
feedback loops
4
Q

how are genes targeted for epigenetic modification?
____________ _______ and _________ ______
-recruit proteins (histone modification, histone acetyltransferase, histone deacetylase, and DNA methyltransferase)

A

transcription factors and noncoding RNA

5
Q

related to cis/trans factors and elements

  • ___ ________ ______(affects 1 gene and 1 copy of gene)
  • _______ _______ ___(affects several genes or several copies of a gene)
A

cis epigen mech

trans epigen mech

6
Q

Epigenetic triggers:

  • __________ ________: genomic imprinting, x chromosome inactivation, cell determination
  • ___________: temp, diet(bees), toxins (cigarettes)
A

programmed development

enviromental

7
Q

igf2 gene encodes critical protein for growth in mice

A

epigenetics and imprinting (methylation)

8
Q

father determines expression of _____ in offspring

A

igf2

9
Q
mechanism of ifg2 expression:
ICR=
DMR=
H19=
CTC=
A

imprinting control region
differentially methylated region
gene associated with cancer
binding factor-igf2 repressor

10
Q

stem cells—>

A

muscle cells

11
Q

atleast two protein complexes involved in Epigenetics and cell determination: _________-gene activation and __________-gene repression
-exert effects by trimethylating __________

A

TrxG, trithorax group
PcG, polycomb group

histones

12
Q

results in different polypeptide products from same gne

-splicing factors=

A

alternate splicing of pre-mRNA

-alpha-tropomyosin pre-mRNA

13
Q

enables mRNA and polypeptide variants and prominence varies by __________

A

alternative splicing

species

14
Q

modulate the spliceosome

-repression (______ skipping)

A

repressors affect alternative splicing of exons

15
Q

modulate the spliceosome

-enhancement

A

enhancers affect alternative splicing of exons

16
Q

another regulatory mechanism
inhibits proliferation of viruses with double stranded RNA genome
regulation of jumping genes (transposable elements)

A

importance of RNAi (interference)

17
Q
  • can promote or inhibit translocation of several genes simultaneously
  • initiation facts required for ribosomal subunits to interact with RNA
A

phosophorylation of initiation factors

18
Q
  • mRNA encoding Ferratin and Transferrin influenced by iron regulatory protein (IRP)
  • IRP binds to iron response element (IRE) in both mRNAs
A

initiation factors and RNA binding proteins regulate iron uptake