Epilepsy

Question 1

Broad (don’t worsen generalized epilepsy)

Answer 1

LEV, LTG, VAP, topiramate, zonisamide

Question 2

Exacerbate myoclonus

Answer 2

gabapentin, pregabalin, vigabatrin, LTG, carbamazepine

Question 3

Exacerbate absence

Answer 3

gabapentin, carbamazepine, phenytoin, LTG

Question 4

Inducers

Answer 4

PPP CT = PHT, PHB, primidone, carbamazepine (self), topiramate (>200 mg/d)

Question 5

Inhibitors

Answer 5

VAP, EPIC = Erythromycin, propoxyphene, isoniazid, CCBs, Cimetidine

Question 6

Absence

Answer 6

3Hz spike-wave

Question 7

JME

Answer 7

4-6Hz polyspike photic

Question 8

Dravet

Answer 8

SCN1A, generalized spike wave, multifocal spikes

Question 9

Otahara

Answer 9

burst suppression

Question 10

Benign neonatal (and familial) seizures

Answer 10

KCNQ2-3, 5d fits

Question 11

LGS

Answer 11

slow 1.5-2Hz spike wave

Question 12

Landau-Kleffner

Answer 12

acquired epileptic aphasia, multifocal spikes

Question 13

ESES

Answer 13

slow spike wave in non-REM

Question 14

Unverricht-Lundborg

Answer 14

EPM1, stimulus induced myoclonus, ataxia, tremor and IQ decline, polyspike-wave

Question 15

Lafora bodies

Answer 15

EPM2A, cherry red spot, skin biopsy

Question 16

N1

Answer 16

roving eyes, vertex sharp waves, POSTS (positive occipital sharp transients of sleep)

Question 17

N2

Answer 17

K complex, sleep spindle

Question 18

N3

Answer 18

dec w/ age, delta

Question 19

REM

Answer 19

(90min) dec w/ age, alpha occipital, sawtooth waves, atonia

Question 20

Klein-Levine

Answer 20

recurrent hypersomnias QMonths, hypersexuality, hyperphagia, normal between