Epilepsy table Flashcards
(24 cards)
First-Line Drugs for Newly Diagnosed
(Adults and Adolescents)
Carbamazepine
Gabapentin
Oxcarbazepine
Phenobarbital
Topiramate
Valproic Acid
(CarGO - PTV)
Alternative Drugs (FDA-Approved) for Newly Diagnosed (Adults and Adolescents)
Carbamazepine
Lacosamide
Phenobarbital
Phenytoin
Topiramate
(CarLa, PhePhe To?)
1st line: Refractory Monotherapy
Lamotrigine
Oxcarbazepine
Topiramate
(LOT)
Alternative: Refractory Monotherapy
Carbamazepine
Lamotrigine
Oxcarbazepine
Phenobarbital
Phenytoin
Topiramate
Valproic Acid
(CarLa, PhePhe Va TO)
1st line: Refractory Adjunct
Gabapentin
Lamotrigine
Levetiracetam
Oxcarbazepine
Tiagabine
Topiramate
Zonisamide
(GaLa Tia LeO ToZ)
Alternative: Refractory Adjunct
Carbamazepine
Gabapentin
Lamotrigine
Levetiracetam
Oxcarbazepine
Phenobarbital
Phenytoin
(CarGa LaLeO PhePhe)
1st line: Children
Gabapentin
Lamotrigine
Oxcarbazepine
Topiramate
(GaLa TO)
Alternative: Children
Pregabalin
Tiagabine
Valproic
Vigabatrine
Zonisamide
(Pre, Tia Val VigaZ)
1st line: Generalized seizures absence (newly diagnosed)
Lamotrigine
Alternative: Generalized seizures absence (newly diagnosed)
Ethosuximide, Valproic
Acid
1st line: Primary generalized (tonic clonic)
topiramate
Alternative: Primary generalized (tonic clonic)
Lamotrigine, Levetiracetam
Alternative: Juvenile myoclonic epilepsy
Levetiracetam
(myoclonic seizures)
Cause fewer cognitive impairments
Gabapentin and
Lamotrigine
May cause substantial cognitive
impairments especially at high
doses or in rapid-dose escalation
Topiramate
Most widely used AEDs
Carbamazepine,
Phenobarbital,
Phenytoin,
Valproic Acid
uperior to valproic acid for efficacy
in the treatment of partial seizures
Carbamazepine
Newer generation agents
● Received FDA approval for use as
monotherapy in patients with partial
seizures
Lamotrigine,
Oxcarbazepine,
Topiramate
traditional treatment
Phenytoin
increasingly used due to lower
incidences of side effects
Carbamazepine and Valproic acid
Tonic-Clonic
Seizures
Carbamazepine and Valproic acid and Phenytoin
Generally considered the drug of
first choice for atonic seizures and
for juvenile myoclonic epilepsy
(JME)
Valproic acid
Alternative agents
Lamotrigine,
Topiramate,
Zonisamide
FDA-approved as adjunctive
treatment of myoclonic seizures in
patients with JME
Levetiracetam
